지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
This study was aimed to evaluate the antimicrobial activity of Penicillium purpurogenum ED76 on several clinically important microorganisms. The endophytic fungus P. purpurogenum ED76 was previously isolated from Swietenia macrophylla leaf. The antimicrobial efficacy of P. purpurogenum ED76 dichloromethane extract was determined via disc diffusion and broth microdilution assay. A kill curve study was conducted and the morphology of extract treated bacterial cells were viewed under scanning electron microscope. The dichloromethane extract showed significant inhibitory activity on 4 test bacteria and 2 test yeasts. The minimal inhibitory concentration of the extract ranged from 125 to 1,000 μg/ml, which indicates the different susceptibility levels of the test microorganisms to the fungal extract. The kill curve study has revealed a concentration-dependent inhibition for all test microorganisms. With the increase of the extract concentration, the microbial growth was significantly reduced. The scanning electron micrograph of dichloromethane extracttreated Staphylococcus aureus cells showed the total damage of the cells. The cell wall invagination of the bacterial cells also indicates the loss of cellular materials and metabolic activity. The gas chromatography mass spectrometry analysis of the extract also showed that the major compound was stigmasterol, which constitutes 45.30% of the total area. The dichloromethane extract of P. purpurogenum ED76 exhibited significant inhibitory activity on several clinically important bacteria and yeasts. The study proposed a possible mode of action that the extract cause significant damage to the morphology of S. aureus cells.
목차
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Andhale, J. D / 2016 / Incidence of Pseudomonas aeruginosa with special reference to drug resistance and biofilm formation from clinical samples in tertiary care hospital / J. Pharm. Biomed. Sci 6 : 6 ~ 10
[학술지(정기간행물)] - Ciusa, M. L / 2012 / A novel resistance mechanism to triclosan that suggests horizontal gene transfer and demonstrates a potential selective pressure for reduced biocide susceptibility in clinical strains of Staphylococcus aureus / Int. J. Antimicrob. Agents 40 : 210 ~ 220
[학술지(정기간행물)] - Darah, I / 2014 / Antimicrobial activity of endophytic fungi isolated from Swietenia macrophylla leaves / Nat. Prod. Commun 9 : 247 ~ 250
[학술지(정기간행물)] - Darah, I / 2015 / Effect of the extract of endophytic fungus, Nigrospora sphaerica CL-OP 30, against the growth of Methicillin-Resistant Staphylococcus aureus (MRSA) and Klebsiella pneumonia cells / Trop. J. Pharm. Res 14 : 2091 ~ 2097
[학술지(정기간행물)] - Friedman, N. D / 2016 / The negative impact of antibiotic resistance / Clin. Microbiol. Infect 5 : 416 ~ 422
[학술지(정기간행물)] - Ciusa, M. L / 2012 / A novel resistance mechanism to triclosan that suggests horizontal gene transfer and demonstrates a potential selective pressure for reduced biocide susceptibility in clinical strains of Staphylococcus aureus / Int. J. Antimicrob. Agents 40 : 210 ~ 220
[학술지(정기간행물)] - Darah, I / 2014 / Antimicrobial activity of endophytic fungi isolated from Swietenia macrophylla leaves / Nat. Prod. Commun 9 : 247 ~ 250
[학술지(정기간행물)] - Darah, I / 2015 / Effect of the extract of endophytic fungus, Nigrospora sphaerica CL-OP 30, against the growth of Methicillin-Resistant Staphylococcus aureus (MRSA) and Klebsiella pneumonia cells / Trop. J. Pharm. Res 14 : 2091 ~ 2097
[학술지(정기간행물)] - Friedman, N. D / 2016 / The negative impact of antibiotic resistance / Clin. Microbiol. Infect 5 : 416 ~ 422
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
황칠나무(Dendropanax morbiferus Lev.) 잎 에탄올 추출물의 항균 및 항산화활성
한국식품조리과학회지
2015 .01
-
Lipopolysaccharide로 자극된 RAW 264.7 세포와 마우스 귀부종 모델에 대한 참치 심장 Dichloromethane 분획물의 항염증 효과
한국미생물·생명공학회지
2017 .06
-
천연물 성분을 이용한 환경 유해미생물의 biofilm 생성 저해능 비교에 관한 연구
한국환경과학회지
2019 .02
-
비자 추출물의 식품부패균에 대한 항균효과 및 항산화활성
한국지역사회생활과학회지
2015 .11
-
Characterization of Antimicrobial Activity and Mechanism of Antimicrobial Peptide against Bacteria
한국미생물학회 학술대회논문집
2016 .04
-
Effects of Solvents with Different Polarities on the Antioxidant Activities of the Leaves and Roots of Allium hookeri
동아시아식생활학회지
2020 .10
-
Synergistic Antimicrobial Effect of Lonicera japonica and Magnolia obovata Extracts and Potential as a Plant-Derived Natural Preservative
Journal of Microbiology and Biotechnology
2018 .01
-
Bioprospecting Endophytic Fungi and Their Metabolites from Medicinal Tree Aegle marmelos in Western Ghats, India
Mycobiology
2015 .01
-
Antimicrobial and Anti-Biofilm Activities of the Methanol Extracts of Medicinal Plants against Dental Pathogens Streptococcus mutans and Candida albicans
Journal of Microbiology and Biotechnology
2017 .07
-
Antimicrobial Activity of Various Parts of Tomato Plants Varied with Different Solvent Extracts
The Plant Pathology Journal
2019 .04
-
Investigation of Antimicrobial Compounds Produced by Endolichenic Fungi in Different Culture Media
The Plant Pathology Journal
2024 .10
-
Inhibitory Effect of Lactobacillus plantarum Extracts on HT-29 Colon Cancer Cell Apoptosis Induced by Staphylococcus aureus and Its Alpha-Toxin
Journal of Microbiology and Biotechnology
2015 .01
-
Penicillium Diversity from Intertidal Zone in Korea
한국균학회 학술대회
2016 .01
-
Antioxidant Activity, Macamide B Content and Muscle Cell Protection of Maca (Lepidium meyenii) Extracted Using Ultrasonification-Assisted Extraction
한국미생물·생명공학회지
2020 .01
-
A New Species of Penicillium Belonging to Section Citrina from Korea with Antimicrobial and Enzymatic Activity
한국미생물학회 학술대회논문집
2019 .04
-
국내에서 수집된 마른진흙버섯 자실체의 항산화 및 항균 효과
대한임상검사과학회지
2016 .01
-
Yeast Extract: Characteristics, Production, Applications and Future Perspectives
Journal of Microbiology and Biotechnology
2023 .02
-
천문동 추출물의 호흡기 세균에 대한 항균활성 및 항산화
한국미생물·생명공학회지
2015 .01
-
Insecticidal Activity of Ethyl Acetate Extracts from Culture Filtrates of Mangrove Fungal Endophytes
Mycobiology
2015 .01
-
Antimicrobial Activities of Omija Extracts Against Bacillus cereus and Escherchia coli
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2018 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-475-001327775