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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 271 - 280 (10page)
이용수
초록· 키워드
오류제보하기
Tertiary lymphoid structures (TLS) are ectopic lymphoid tissues involved in chronic inflammation, autoimmune diseases, transplant rejection and cancer. They exhibit almost all the characteristics of secondary lymphoid organs (SLO), which are associated with adaptive immune responses; as such, they contain organized B-cell follicles with germinal centers, distinct areas containing T cells and dendritic cells, high endothelial venules, and lymphatics. In this review, we briefly describe the formation of SLO, and describe the cellular subsets and molecular cues involved in the formation and maintenance of TLS. Finally, we discuss the associations of TLS with human diseases, especially autoimmune diseases, and the potential for therapeutic targeting.
목차
DEVELOPMENT OF SECONDARY LYMPHOID ORGANS (SLO)
DEFINITION OF TERTIARY LYMPHOID STRUCTURES(TLS)
CELLULAR COMPOSITION OF TERTIARY LYMPHOID STRUCTURES
CYTOKINES AND CHEMOKINES IN TLS
TLS IN HUMAN DISEASES
TLS AS PROMISING TARGETS FOR THE TREAT MENT OF HUMAN DISEASES
CONCLUDING REMARKS
REFERENCES
참고문헌 (93)
참고문헌 신청
van de Pavert, S. A / 2010 / New insights into the development of lymphoid tissues / Nat. Rev. Immunol 10:664~674
Carragher, D. M / 2008 / Ectopic lymphoid tissues and local immunity / Semin. Immunol 20:26~42
Joshi, N. S / 2015 / Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses / Immunity 43:579~590
Stranford, S / 2012 / Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma / Front. Immunol 3:350
Aloisi, F / 2006 / Lymphoid neogenesis in chronic inflammatory diseases / Nat. Rev. Immunol 6:205~217
Carragher, D. M / 2008 / Ectopic lymphoid tissues and local immunity / Semin. Immunol 20:26~42
Joshi, N. S / 2015 / Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses / Immunity 43:579~590
Stranford, S / 2012 / Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma / Front. Immunol 3:350
Aloisi, F / 2006 / Lymphoid neogenesis in chronic inflammatory diseases / Nat. Rev. Immunol 6:205~217
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UCI(KEPA) : I410-ECN-0101-2017-517-001663399