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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.10
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- 1 - 16 (16page)
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Autoimmune diseases are caused by a dysfunction of the acquired immune system. In a subset of autoimmune diseases, B cells escaping immune tolerance present autoantigen and produce cytokines and/or autoantibodies, resulting in systemic or organ-specific autoimmunity. Therefore, B cell depletion with monoclonal Abs targeting B cell lineage markers is standard care therapy for several B cell-mediated autoimmune disorders. In the last 5 years, genetically-engineered cellular immunotherapies targeting B cells have shown superior efficacy and long-term remission of B cell malignancies compared to historical clinical outcomes using B cell depletion with monoclonal Ab therapies. This has raised interest in understanding whether similar durable remission could be achieved with use of genetically-engineered cell therapies for autoimmunity. This review will focus on current human clinical trials using engineered cell therapies for B cell-associated autoimmune diseases.
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ABSTRACT
INTRODUCTION
B CELL TARGETING STRATEGIES IN AUTOIMMUNE DISEASES
CLINICAL TRIALS EVALUATING ENGINEERED CELLULAR THERAPIES FOR AUTOIMMUNE DISEASES
FUTURE DIRECTIONS
REFERENCES
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