지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.30
- 발행연도
- 2015.12
- 수록면
- 43 - 49 (7page)
이용수
초록· 키워드
오류제보하기
Objectives: This study aimed to estimate the effects of 4-nonylphenol (NP), a ubiquitously present surfactant in aquatic environments, on the anti-oxidant systems of the liver in the Far Eastern catfish Silurus asotus.
Methods: Changes in biochemical parameters involved in glutathione (GSH)-related and other anti-oxidant systems were analyzed following 4 weeks of 4-NP administration(0.1 and 1.0 mg/kg diet) via a formulated diet to catfish.
Results: 4-NP exposure induced an elevation in hepatic lipid peroxide levels and an accompanying decrease in reduced state GSH after 2 weeks, suggesting pro-oxidant effects of the chemical in catfish. This oxidative stress was associated with an inhibition of the GSH-utilizing enzyme glutathione peroxidase at the same time point. This inhibition was restored after 4 weeks. The activities of other anti-oxidant enzymes, i.e., glutathione reductase, superoxide dismutase and catalase were increased after 4 weeks. These enzyme increases occurred more strongly at the higher 4-NP concentration (1.0 mg/kg diet).
Conclusions: 4-NP given to catfish at 0.1 to 1.0 mg/kg diet, concentrations relevant to environmental levels, depletes the endogenous anti-oxidant molecule GSH and temporarily inhibits GSH-related anti-oxidant enzymes. Such declines in anti-oxidant capacity and elevated oxidative stress seem to be compensated eventually by subsequent activation of various anti-oxidant enzyme systems.
Methods: Changes in biochemical parameters involved in glutathione (GSH)-related and other anti-oxidant systems were analyzed following 4 weeks of 4-NP administration(0.1 and 1.0 mg/kg diet) via a formulated diet to catfish.
Results: 4-NP exposure induced an elevation in hepatic lipid peroxide levels and an accompanying decrease in reduced state GSH after 2 weeks, suggesting pro-oxidant effects of the chemical in catfish. This oxidative stress was associated with an inhibition of the GSH-utilizing enzyme glutathione peroxidase at the same time point. This inhibition was restored after 4 weeks. The activities of other anti-oxidant enzymes, i.e., glutathione reductase, superoxide dismutase and catalase were increased after 4 weeks. These enzyme increases occurred more strongly at the higher 4-NP concentration (1.0 mg/kg diet).
Conclusions: 4-NP given to catfish at 0.1 to 1.0 mg/kg diet, concentrations relevant to environmental levels, depletes the endogenous anti-oxidant molecule GSH and temporarily inhibits GSH-related anti-oxidant enzymes. Such declines in anti-oxidant capacity and elevated oxidative stress seem to be compensated eventually by subsequent activation of various anti-oxidant enzyme systems.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (30)
참고문헌 신청
Soverchia L. / 2005 / Modulation of vitellogenin synthesis through estrogen receptor beta-1 in goldfish(Carassius auratus)juveniles exposed to 17-beta estradiol and nonylphenol / Toxicol Appl Pharmacol 209(3):236~243
Lacorte S. / 2006 / Pilot survey of a broad range of priority pollutants in sediment and fish from the Ebro river basin(NE Spain) / Environ Pollut 140(3):471~482
European Chemicals Agency. / Support document for identification of 4-nonylphenol, branched and linear, ethoxylated
Ahel M. / 1993 / Bioaccumulation of the lipophilic metabolites of nonionic surfactants in freshwater organisms / Environ Pollut 79(3):243~248
Pomatto V. / 2011 / Xenoestrogens elicit a modulation of endocannabinoid system and estrogen receptors in 4NP treated goldfish, Carassius auratus / Gen Comp Endocrinol 174(1):30~35
Lacorte S. / 2006 / Pilot survey of a broad range of priority pollutants in sediment and fish from the Ebro river basin(NE Spain) / Environ Pollut 140(3):471~482
European Chemicals Agency. / Support document for identification of 4-nonylphenol, branched and linear, ethoxylated
Ahel M. / 1993 / Bioaccumulation of the lipophilic metabolites of nonionic surfactants in freshwater organisms / Environ Pollut 79(3):243~248
Pomatto V. / 2011 / Xenoestrogens elicit a modulation of endocannabinoid system and estrogen receptors in 4NP treated goldfish, Carassius auratus / Gen Comp Endocrinol 174(1):30~35
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
가지-청열소독음(淸熱消毒飮)의 항산화 및 항염 효능에 관한 연구
대한화장품학회지
2017 .01
-
가미소요산의 새로운 제형에 대한 항산화 활성 및 항염증 효능평가
대한본초학회지(본초분과학회지)
2016 .01
-
초법에 따른 당귀의 항산화 및 항혈전 효과
대한본초학회지(본초분과학회지)
2016 .01
-
Screening for anti-inflammation and anti-oxidant effects of mongolian plant extracts
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Crocin Improves Oxidative Stress by Potentiating Intrinsic Anti-Oxidant Defense Systems in Pancreatic Cells During Uncontrolled Hyperglycemia
Journal of Pharmacopuncture
2019 .01
-
A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities
Journal of Pharmacopuncture
2019 .01
-
Effects of reduced glutathione on stress and inflammatory response in Korean native calves vaccinated with foot-and-mouth disease vaccine
예방수의학회지
2018 .03
-
LPS로 유도된 RAW 264.7 세포에서 오성탕(五聖湯) 추출물의 항염증 및 항산화 연구
한방안이비인후피부과학회지
2020 .01
-
Anti-inflammatory and Anti-oxidant Activities of Aster Scaber Ethanol Extract
대한의생명과학회지
2022 .09
-
First report of tetracycline-resistant Aeromonas veronii infection in Amur catfish (Silurus asotus) cultured in Korea
Korean Journal of Veterinary Research(대한수의학회지)
2020 .02
-
추출 조건에 따른 오미자 열매 추출물의 lignan 성분들의 함량 분석 및 항산화 효과
생약학회지(Korean Journal of Pharmacognosy)
2024 .06
-
Anti-oxidant and anti-inflammatory effects of Salix Koreensis Andersson in DC. leaf methanol extract in vitro models
셀메드
2016 .11
-
Comparative and Interactive Biochemical Effects of Sub-Lethal Concentrations of Cadmium and Lead on Some Tissues of the African Catfish (Clarias gariepinus)
Toxicological Research
2019 .07
-
Anti-oxidant, Anti-inflammatory, and Anti-obesity Effects of Ethanol Extracts from Ulmus divididiana var. japonica
대한의생명과학회지
2019 .09
-
배롱나무의 항산화 활성 성분
생약학회지(Korean Journal of Pharmacognosy)
2016 .09
-
Anti-obesity effect of blueberry fermented liquid for companion animals using blueberry by-products
한국실험동물학회 학술발표대회 논문집
2019 .07
-
오수유(吳茱萸) 추출물이 만성 역류성 식도염 흰쥐에 미치는 효능 평가
대한본초학회지(본초분과학회지)
2019 .01
-
LPS로 유도된 RAW 264.7 대식세포주에서 內疎黃連湯의 항염증 기전 및 항산화 효능 연구
한방안이비인후피부과학회지
2020 .01
-
Evaluation of Oxidant/Antioxidant Status and Cytokine Levels in Patients with Cannabis Use Disorder
Clinical Psychopharmacology and Neuroscience
2017 .08
-
Anti-Inflammatory Effects of Tongbi-san(通痺散) Extract on RAW264.7 Macrophages
한방안이비인후피부과학회지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-539-000798842