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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 30 - 40 (11page)
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Objectives: The aim of this study was whether quercetin induces cell death by caspase and MAPK signaling pathway in EGFR mutant lung cancer cells Methods: PC-9 cells, EGFR mutant lung cancer cells, were treated various times and concentrations of quercetin and harvested and measured using MTT assay, DNA fragmentation, Western blotting, and FACS analysis. Results: Treatment with quercetin in PC-9 cells resulted in inhibition of cell growth through apoptosis. Quercetin-induced apoptosis was associated with caspase-dependent manner. Quercetin also significantly increased levels of phosphor-p38 and decreased levels of phosphor-ERK, indicating that quercetin induces p38 MAPK signaling pathway in PC-9 cells. Quecetin treatment also generated the release of cytochrome c in PC-9 cells; however, pretreatment with rotenone or z-LEHD-fmk, significantly attenuated quercetin-induced apoptosis. Conclusions: Our data indicate that quercetin exhibits EGFR mutant lung cancer effects through apoptosis by caspase dependent and mitochondrial pathway.
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참고문헌 (24)
참고문헌 신청
Socinski MA / 2003 / American Society of Clinical Oncology Education Book / Lisa Greaves :144~152
Nocholosn RI / 2001 / EGFR and cancer prognosis / Eur J Cancer 37:S9~S15
Wätjen W / 2005 / Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis / J Nutr 135:525~531
Vargas AJ / 2010 / Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management / Nutr Rev 68:418~428
Chirumbolo S / 2010 / The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm / Allergy Drug Targets 9:263~285
Nocholosn RI / 2001 / EGFR and cancer prognosis / Eur J Cancer 37:S9~S15
Wätjen W / 2005 / Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis / J Nutr 135:525~531
Vargas AJ / 2010 / Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management / Nutr Rev 68:418~428
Chirumbolo S / 2010 / The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm / Allergy Drug Targets 9:263~285
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Quercetin reduces the injury-induced reduction of γ-enolase expression in a middle cerebral artery occlusion animal model
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Modulation of the Expression of the GABAA Receptor β1 and β3 Subunits by Pretreatment with Quercetin in the KA Model of Epilepsy in Mice
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Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation
Journal of Obesity & Metabolic Syndrome
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The application of transgenic mice with mutant EGFR in drug development and biological role
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