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논문 기본 정보

자료유형
학술저널
저자정보
Sang-Chul Han (Jeju National University) Na-Jin Kang (Jeju National University) Weon-Jong Yoon (Jeju Technopark (JTP)) Sejin Kim (Jeju National University) Min-Chull Na (Jeju National University) Young-Sang Koh (Jeju National University) Jin-Won Hyun (Jeju National University) Nam-Ho Lee (Jeju National University) Mi-Hee Ko (Jeju Technopark (JTP)) Hee-Kyoung Kang (Jeju National University) Eun-Sook Yoo (Jeju National University)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.32 No.2
발행연도
2016.4
수록면
109 - 114 (6page)

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초록· 키워드

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Allergic skin inflammation such as atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. The anti-inflammatory effects of Apo-9"-fucoxanthinone, isolated from Sargassum muticum, have been described in many diseases, but the mechanism by which it modulates the immune system is poorly understood. In this study, the ability of Apo-9"-fucoxanthinone to suppress allergic reactions was investigated using a mouse model of atopic dermatitis. The Apo-9"-fucoxanthinone-treated group showed significantly decreased immunoglobulin E in serum. Also, Apo-9"-fucoxanthinone treatment resulted in a smaller lymph node size with reduced the thickness and length compared to the induction group. In addition, Apo-9"-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. These results suggest that Apo-9"-fucoxanthinone may be a useful therapeutic strategy for treating chronic inflammatory diseases.

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INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2016-513-002786568