지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 201 - 207 (7page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Changes in lipid profiles in patients infected with hepatitis C virus (HCV) during direct-acting antiviral therapy have been reported in recent years. However, the clinical aspects of disturbed lipid metabolism in chronic HCV infection have not been fully elucidated. Methods: Dynamic changes in serum total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol and apolipoprotein levels in patients infected with HCV genotype 1b were examined during combination therapy with daclatasvir (DCV) and asunaprevir (ASV). Results: Total, LDL-, and HDL-cholesterol levels increased rapidly and persistently after week 4. Apolipoprotein (apo) A-I, apo B, apo C-II, and apo C-III levels were significantly higher at week 4 than at week 0. In contrast, apo A-II and apo E levels were significantly lower. The differences in LDL- and HDL-cholesterol levels were positively correlated with those of apo B and apo A-I, respectively. Interestingly, in patients with non-sustained virological response, these cholesterol levels decreased rapidly after viral breakthrough or viral relapse. Furthermore, similar changes were observed for apo A-I, apo B and apo C-III levels. Conclusions: Clearance of HCV using combination therapy with DCV and ASV results in rapid changes in serum lipid profiles, suggesting an influence of HCV infection on disturbed lipid metabolism.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Syed GH / 2010 / Hepatitis C virus hijacks host lipid metabolism / Trends Endocrinol Metab 21:33~40
Hui JM / 2003 / Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected] / Gastroenterology 125:1695~1704
Felmlee DJ / 2013 / Hepatitis C virus, cholesterol and lipoproteins: impact for the viral life cycle and pathogenesis of liver disease / Viruses 5:1292~1324
Andre P / 2002 / Characterization of low- and very-low-density hepatitis C virus RNA-containing particles / J Virol 76:6919~6928
Diaz O / 2006 / Preferential association of hepatitis C virus with apolipoprotein B48-containing lipoproteins / J Gen Virol 87:2983~2991
Hui JM / 2003 / Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected] / Gastroenterology 125:1695~1704
Felmlee DJ / 2013 / Hepatitis C virus, cholesterol and lipoproteins: impact for the viral life cycle and pathogenesis of liver disease / Viruses 5:1292~1324
Andre P / 2002 / Characterization of low- and very-low-density hepatitis C virus RNA-containing particles / J Virol 76:6919~6928
Diaz O / 2006 / Preferential association of hepatitis C virus with apolipoprotein B48-containing lipoproteins / J Gen Virol 87:2983~2991
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Comparison of Apolipoprotein E Polymorphism in Alzheimer’s Disease and Subcortical Vascular Dementia in Koreans
Dementia and Neurocognitive Disorders(대한치매학회지)
2015 .01
-
임신 초기 대사증후군과 임신 예후와의 연관성
Perinatology
2023 .03
-
External Application of Apo-9"-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis
Toxicological Research
2016 .04
-
Efficacy and safety of daclatasvir and asunaprevir for hepatitis C virus genotype 1b infection
Clinical and Molecular Hepatology
2016 .01
-
Efficacy and safety of daclatasvir plus asunaprevir for Korean patients with HCV genotype Ib infection: a retrospective multi-institutional study
Clinical and Molecular Hepatology
2017 .01
-
Hepatitis C Viral Infection in Children: Updated Review
Pediatric Gastroenterology, Hepatology & Nutrition
2016 .01
-
Clinical Utility of a New Automated Hepatitis C Virus Core Antigen Assay for Prediction of Treatment Response in Patients with Chronic Hepatitis C
Journal of Korean Medical Science
2016 .01
-
Cost-effectiveness of chronic hepatitis C screening and treatment
Clinical and Molecular Hepatology
2022 .04
-
The Korean Hepatitis C Virus Care Cascade in a Tertiary Institution: Current Status and Changes in Testing, Link to Care, and Treatment
Gut and Liver
2022 .11
-
Hepatocytes infected with hepatitis C virus change immunological features in the liver microenvironment
Clinical and Molecular Hepatology
2023 .01
-
Prevalence, Awareness, and Treatment of Hepatitis C Virus Infection in South Korea: Evidence from the Korea National Health and Nutrition Examination Survey
Gut and Liver
2020 .01
-
Efficacy and Safety of Daclatasvir and Asunaprevir in Patients with Hepatitis C Virus Genotype 1b Infection on Hemodialysis
Gut and Liver
2019 .01
-
C형 간염의 역학
대한내과학회지
2015 .01
-
Clinical Characteristics and Treatment Outcomes of Patients with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection: Experience at a Single Center in Korea
Journal of Korean Medical Science
2021 .11
-
The Applications of Hepatitis C Virus (HCV) Replication System in Developing Anti-HCV Reagents
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .06
-
Reactivation of Hepatitis C Virus and Its Clinical Outcomes in Patients Treated with Systemic Chemotherapy or Immunosuppressive Therapy
Gut and Liver
2017 .01
-
Differences in Hematological Characteristics, Including Cholesterol and Apolipoprotein B and E, between Hepatitis B Virus and Hepatitis C Virus Patients in Korea
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .09
-
Clinical Characteristics and Treatment Outcome of Peginterferon Plus Ribavirin in Patients Infected with Genotype 6 Hepatitis C Virus in Korea: A Multicenter Study
Gut and Liver
2017 .01
-
항암치료 받는 악성 뇌종양 환자의 재발여부에 따른 지질프로필 비율의 비교
기초간호자연과학회지
2017 .01
-
농축기술을 이용한 HCV 저역가 감염혈액의 유전자형 분석
대한수혈학회지
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0