지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 195 - 201 (7page)
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초록· 키워드
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The anti-inflammatory effects of glycosaminoglycan (GAG) derived from Isaria sinclairii (IS) and of IS extracts were investigated in a complete Freund’s adjuvant (CFA)-treated chronic arthritis rat model. Groups of rats were treated orally with 30 mg/kg one of the following: [1] saline control, extracts of [2] water-IS, [3] methanol-IS, [4] butanol-IS, [5] ethyl acetate-IS, or [6] Indomethacin® as the positive control for a period of two weeks. The anti-paw edema effects of the individual extracts were in the following order: water-IS ex. > methanol ex. > butanol ex. > ethyl acetate ex. The water/methanol extract from I. sinclairii remarkably inhibited UV-mediated upregulation of NF-κB activity in transfected HaCaT cells. GAG as a water-soluble alcohol precipitated fraction also produced a noticeable anti-edema effect. This GAG also inhibited the pro-inflammatory cytokine levels of prostaglandin E₂-stimulated lipopolysaccharide in LAW 264.7 cells, cytokine TNF-α production in splenocytes, and atherogenesis cytokine levels of vascular endothelial growth factor (VEGF) production in HUVEC cells in a dose-dependent manner. In the histological analysis, the LV dorsal root ganglion, including the articular cartilage, and linked to the paw-treated IS GAG, was repaired against CFA-induced cartilage destruction. Combined treatment with Indomethacin® (5 mg/kg) and IS GAG (10 mg/kg) also more effectively inhibited CFA-induced paw edema at 3 hr, 24 hr, and 48 hr to levels comparable to the anti-inflammatory drug, indomethacin. Thus, the IS GAG described here holds great promise as an anti-inflammatory drug in the future.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (16)
참고문헌 신청
Ahn, M. Y. / 2007 / Antiobesity effects of Isaria sinclairii by repeated oral treatment in obese Zucker rats over a 4-month period / J. Toxicol. Environ. Health Part A 70:1395~1401
안미영 / 2007 / Anti-hypertensive Effect of the Dongchunghacho, Isaria sinclairii, in the Spontaneously Hypertensive Rats / Archives of Pharmacal Research 30(4):493~501
Ahn, M. Y. / 2010 / Antidiabetic effects and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month period / J. Toxicol. Environ. Health Part A 73:1511~1520
Mi Young Ahn / 2008 / Antioxidant Activity of N-hydroxyethyl Adenosine from Isaria sinclairii / International Journal of Industrial Entomology 17(2):197~200
Ueda, H. / 2005 / Preoperative administration of FTY720 prolonged renal allograft survival / Transplant Immunol. 14:1~8
안미영 / 2007 / Anti-hypertensive Effect of the Dongchunghacho, Isaria sinclairii, in the Spontaneously Hypertensive Rats / Archives of Pharmacal Research 30(4):493~501
Ahn, M. Y. / 2010 / Antidiabetic effects and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month period / J. Toxicol. Environ. Health Part A 73:1511~1520
Mi Young Ahn / 2008 / Antioxidant Activity of N-hydroxyethyl Adenosine from Isaria sinclairii / International Journal of Industrial Entomology 17(2):197~200
Ueda, H. / 2005 / Preoperative administration of FTY720 prolonged renal allograft survival / Transplant Immunol. 14:1~8
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UCI(KEPA) : I410-ECN-0101-2014-510-002864119