지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 252 - 259 (8page)
이용수
초록· 키워드
오류제보하기
Hematopoietic stem and progenitor cells (HSPCs) can produce all kind of blood lineage cells, and gut microbiota that consists of various species of microbe affects development and maturation of the host immune system including gut lymphoid cells and tissues. However, the effect of altered gut microbiota composition on homeostasis of HSPCs remains unclear. Here we show that compositional change of gut microbiota affects homeostasis of HSPCs using Rag1<SUP>−/−</SUP> mice which represent lymphopenic condition. The number and proportions of HSPCs in Rag1<SUP>−/−</SUP> mice are lower compared to those of wild types. However, the number and proportions of HSPCs in Rag1<SUP>−/−</SUP> mice are restored as the level of wild types through alteration of gut microbiota diversity via transferring feces from wild types. Gut microbiota composition of Rag1<SUP>−/−</SUP> mice treated with feces from wild types shows larger proportions of family Prevotellaceae and Helicobacterceae whereas lower proportions of family Lachnospiraceae compared to unmanipulated Rag1<SUP>−/−</SUP> mice. In conclusion, gut microbiota composition of lymphopenic Rag1<SUP>−/−</SUP> mice is different to that of wild type, which may lead to altered homeostasis of HSPCs.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (18)
참고문헌 신청
[학술지(정기간행물)] - Kondo, M. / 2003 / Biology of hematopoietic stem cells progenitors: implications for clinical application / Annu. Rev. Immunol 21 : 759 ~ 806
[학술지(정기간행물)] - Warr, M. R. / 2011 / Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis hematological malignancies / Wiley Interdiscip. Rev. Syst. Biol. Med 3 : 681 ~ 701
[학술지(정기간행물)] - van der Wath, R. C. / 2009 / Estimating dormant active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics / PLoS One : e6972 ~
[학술지(정기간행물)] - Trumpp, A. / 2010 / Awakening dormant haematopoietic stem cells / Nat. Rev. Immunol 10 : 201 ~ 209
[학술지(정기간행물)] - Wilson, A. / 2006 / Bone-marrow haematopoietic-stem-cell niches / Nat. Rev. Immunol 6 : 93 ~ 106
[학술지(정기간행물)] - Warr, M. R. / 2011 / Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis hematological malignancies / Wiley Interdiscip. Rev. Syst. Biol. Med 3 : 681 ~ 701
[학술지(정기간행물)] - van der Wath, R. C. / 2009 / Estimating dormant active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics / PLoS One : e6972 ~
[학술지(정기간행물)] - Trumpp, A. / 2010 / Awakening dormant haematopoietic stem cells / Nat. Rev. Immunol 10 : 201 ~ 209
[학술지(정기간행물)] - Wilson, A. / 2006 / Bone-marrow haematopoietic-stem-cell niches / Nat. Rev. Immunol 6 : 93 ~ 106
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UCI(KEPA) : I410-ECN-0101-2016-511-002009693