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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 66 - 72 (7page)
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Currently, detecting biochemical differences before and after allogeneic stem cell transplantation (SCT) for improved prediction of acute graft-versus-host disease (aGVHD) is a major clinical challenge. In this pilot study, we analyzed the kinetics of circulating adipokine levels in patients with or without aGVHD before and after allogeneic SCT. Serum samples were obtained and stored at ?80oC within 3 hours after collection, prior to conditioning and at engraftment after transplantation. A protein array system was used to measure the levels of 7 adipokines of patients with aGVHD (n=20) and without aGVHD (n=20). The resistin level at engraftment was significantly increased (p＜0.001) after transplantation, regardless of aGVHD occurrence. In the non-aGVHD group, the concentrations of the hepatocyte growth factor (HGF) (mean values±SD; 206.6±34.3 vs. 432.3±108.9 pg/ml, p=0.040) and angiopoietin-2 (ANG-2) (mean values±SD; 3,197.2±328.3 vs. 4,471.8±568.4 pg/ml, p=0.037) at engraftment were significantly higher than those of the pre-transplant period, whereas in the aGVHD group, the levels of adipokines did not change after transplantation. Our study suggests that changes in serum HGF and ANG-2 levels could be considered helpful markers for the subsequent occurrence of aGVHD.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Coghill, J. M. / 2011 / Effector CD4＋ T cells, the cytokines they generate, GVHD : something old something new / Blood 117 : 3268 ~ 3276
2. [학술지(정기간행물)] - Roy, J. / 1995 / The tissue expression of cytokines in human acute cutaneous graft-versus-host disease / Transplantation 60 : 343 ~ 348
3. [학술지(정기간행물)] - Tanaka, J. / 1993 / Cytokine gene expression in peripheral blood mononuclear cells during graft-versus-host disease after allogeneic bone marrow transplantation / Br. J. Haematol 85 : 558 ~ 565
4. [학술지(정기간행물)] - Carayol, G. / 1997 / Quantitative analysis of T helper 1, T helper 2, inflammatory cytokine expression in patients after allogeneic bone marrow transplantation : relationship with the occurrence of acute graft-versus-host disease / Transplantation 63 : 1307 ~ 1313
5. [학술지(정기간행물)] - Faaij, C. M. / 2006 / A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease / Br. J. Haematol 133 : 538 ~ 549
2. [학술지(정기간행물)] - Roy, J. / 1995 / The tissue expression of cytokines in human acute cutaneous graft-versus-host disease / Transplantation 60 : 343 ~ 348
3. [학술지(정기간행물)] - Tanaka, J. / 1993 / Cytokine gene expression in peripheral blood mononuclear cells during graft-versus-host disease after allogeneic bone marrow transplantation / Br. J. Haematol 85 : 558 ~ 565
4. [학술지(정기간행물)] - Carayol, G. / 1997 / Quantitative analysis of T helper 1, T helper 2, inflammatory cytokine expression in patients after allogeneic bone marrow transplantation : relationship with the occurrence of acute graft-versus-host disease / Transplantation 63 : 1307 ~ 1313
5. [학술지(정기간행물)] - Faaij, C. M. / 2006 / A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease / Br. J. Haematol 133 : 538 ~ 549
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UCI(KEPA) : I410-ECN-0101-2016-511-001746306