Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea

Kyoung Min Lee; Won Ki Ahn; Jung Woo Han; Chuhl Joo Lyu; Seung Min Hahn

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자료유형: 학술저널

저자정보: Kyoung Min Lee (Division of Pediatric Hematology and Oncology Department of Pediatrics Yonsei University College of Medicine Seoul Korea) Won Ki Ahn (Division of Pediatric Hematology and Oncology Department of Pediatrics Yonsei University College of Medicine Seoul Korea) Jung Woo Han (Division of Pediatric Hematology and Oncology Department of Pediatrics Yonsei University College of Medicine Seoul Korea) Chuhl Joo Lyu (Division of Pediatric Hematology and Oncology Department of Pediatrics Yonsei University College of Medicine Seoul Korea) Seung Min Hahn (Division of Pediatric Hematology and Oncology Department of Pediatrics Yonsei University College of Medicine Seoul Korea)

저널정보: 대한소아혈액종양학회 Clinical Pediatric Hematology-Oncology Clinical Pediatric Hematology-Oncology Vol.30 No.1

발행연도: 2023.4

수록면: 11 - 20 (10page)

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Background: Acute complications within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT) can increase immediate mortality as well as the risk of chronic complications and morbidity. A comprehensive review collecting systemic complications following transplantation would be important in pediatric patients. Methods: We report a retrospective study of pediatric patients who underwent alloge-neic HSCT during the 11 years (2009-2020), and their acute complications after transplantation within 100 days. A total 227 pediatric patients’ (90 females, 137 males) data were collected. Results: Among the patients, 62.6% (N=142) suffered from acute graft-versus-host dis-ease, and 118 (52.0%) patients had an acute infection. Pulmonary complications oc-curred in 52 (22.9%) patients followed by hepatic sinusoidal obstruction syndrome in 30 (18.1%) patients. In the study, 19 died within the first 100 days after HSCT (8.4%), and the 5-year overall survival rate of the patients was 65.4%. Conclusion: This study widens the understanding of acute toxicities of pediatric HSCT. A significant number of children still have experienced a variety of acute in-fectious or non-infectious complications after allogeneic HSCT that contribute to morbidity and mortality. Therefore, continuous efforts are needed to reduce them.

#Hematopoietic stem cell transplantation #Pediatric #Graft versus host dis-ease #Infection

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