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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,373 - 1,382 (10page)
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Experimental stem cell therapy for spinal cord injury (SCI) has been extensively investigated. The selection of effective cell transplantation route is also an important issue. Although various types of scaffold have been widely tried as a carrier of stem cells to the injured spinal cord, there was little comparative study to investigate the efficacy of transplantation comparing with conventional transplantation route. A total of 48 Sprague- Dawley rats were subjected to standardized SCI, followed by transplantation of allogeneic mesenchymal stem cells (MSCs), either via intralesional injection (IL group), or via the poly (lactic-co-glycolic acid) (PLGA) scaffold (IP group) or chitosan scaffold (IC group). Engraftment and differentiation of the transplanted cells, expression of neurotrophic factors in the injured spinal cord, and functional recovery were compared with those of the control group. The mean numbers of engrafted MSCs in the IL, IP, and IC groups were 20.6 ± 0.7, 25.6 ± 1.7, and 26.7 ± 1.8, cells/high power filed (HPF) respectively. Results showed higher success rate of MSCs engraftment in the scaffold groups compared to the IL group. Expression of neuroprotective growth factors in the SCI lesions showed no significant differences between the IL, IP, and IC groups. The mean Basso, Beattie and Bresnahan locomotor scales at 6 weeks post-transplantation in the IL, IP, IC, and control groups were 7.9 ± 1.1, 7.9 ± 2.1, 8.7 ± 2.1, and 2.9 ± 1.0, respectively. The functional improvement was most excellent in the IC group. The scaffold based MSC transplantation for acute SCI presented the better cell engraftment and neuroprotective effect compared to the intralesional injection transplantation.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Kamada T / 2011 / Transplantation of human bone marrow stromal cell-derived Schwann cells reduces cystic cavity and promotes functional recovery after contusion injury of adult rat spinal cord / Neuropathology 31:48~58
Lu P / 2005 / BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury / Exp Neurol 191:344~360
Uccelli A / 2011 / Neuroprotective features of mesenchymal stem cells / Best Pract Res Clin Haematol 24:59~64
Chu K / 2004 / Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia / Brain Res 1016:145~153
Khang G / 2012 / Neurogenesis of bone marrow-derived mesenchymal stem cells onto β-mercaptoethanol-loaded PLGA film / Cell Tissue Res 347:713~724
Lu P / 2005 / BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury / Exp Neurol 191:344~360
Uccelli A / 2011 / Neuroprotective features of mesenchymal stem cells / Best Pract Res Clin Haematol 24:59~64
Chu K / 2004 / Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia / Brain Res 1016:145~153
Khang G / 2012 / Neurogenesis of bone marrow-derived mesenchymal stem cells onto β-mercaptoethanol-loaded PLGA film / Cell Tissue Res 347:713~724
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