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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.31 No.2
발행연도
2015.6
수록면
181 - 189 (9page)

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In recent years, the use of both nano- and micro-sized lanthanum has been increasing in the production of optical glasses, batteries, alloys, etc. However, a hazard assessment has not been performed to determine the degree of toxicity of lanthanum. Therefore, the purpose of this study was to identify the toxicity of both nano- and micro-sized lanthanum oxide in cultured cells and rats. After identifying the size and the morphology of lanthanum oxides, the toxicity of two different sized lanthanum oxides was compared in cultured RAW264.7 cells and A549 cells. The toxicity of the lanthanum oxides was also analyzed using rats. The half maximal inhibitory concentrations of micro-La₂O₃ in the RAW264.7 cells, with and without sonication, were 17.3 and 12.7 times higher than those of nano-La₂O₃, respectively. Similar to the RAW264.7 cells, the toxicity of nano-La₂O₃ was stronger than that of micro-La₂O₃ in the A549 cells. We found that nano-La₂O₃ was absorbed in the lungs more and was eliminated more slowly than micro-La₂O₃. At a dosage that did not affect the body weight, numbers of leukocytes, and concentrations of lactate dehydrogenase and albumin in the bronchoalveolar lavage (BAL) fluids, the weight of the lungs increased. Inflammatory effects on BAL decreased over time, but lung weight increased and the proteinosis of the lung became severe over time. The effects of particle size on the toxicity of lanthanum oxides in rats were less than in the cultured cells. In conclusion, smaller lanthanum oxides were more toxic in the cultured cells, and sonication decreased their size and increased their toxicity. The smaller-sized lanthanum was absorbed more into the lungs and caused more toxicity in the lungs. The histopathological symptoms caused by lanthanum oxide in the lungs did not go away and continued to worsen until 13 weeks after the initial exposure.
#Lanthanum oxide #Nano #Particle size #Toxicity

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (16)

참고문헌 신청
Heuck, F. / 1968 / Cer-pneumoconiosis / Am. J. Roentgenol. 104:780~783 google schola 임경택 / 2013 / Toxicological Evaluations of Rare Earths and Their Health Impacts to Workers: A Literature Review / Safety and Health at Work 4(1):12~26 Crossref British Geological Survey / 2011 / Rare Earth Element :1~53 google schola Geraets, L. / 2012 / Tissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: results from a 28-day exposure study / Toxicol. Sci. 127:463~473 google schola Gosens, I. / 2014 / Comparative hazard identification of nano-and micro-sized cerium oxide particles based on 28-day inhalation studies in rats / Nanotoxicology 8:643~653 google schola

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