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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.30
- 발행연도
- 2015.12
- 수록면
- 50 - 56 (7page)
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초록· 키워드
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Objectives: The widely promising applications of graphene nanomaterials raise considerable concerns regarding their environmental and human health risk assessment. The aim of the current study was to evaluate the toxicity profiling of graphene family nananomaterials (GFNs) in alternative in vitro and in vivo toxicity testing models.
Methods: The GFNs used in this study are graphene nanoplatelets ([GNPs]–pristine, carboxylate [COOH] and amide [NH2]) and graphene oxides (single layer [SLGO] and few layers [FLGO]). The human bronchial epithelial cells (Beas2B cells) as in vitro system and the nematode Caenorhabditis elegans as in vivo system were used to profile the toxicity response of GFNs. Cytotoxicity assays, colony formation assay for cellular toxicity and reproduction potentiality in C. elegans were used as end points to evaluate the GFNs’ toxicity.
Results: In general, GNPs exhibited higher toxicity than GOs in Beas2B cells, and among the GNPs the order of toxicity was pristine>NH2>COOH. Although the order of toxicity of the GNPs was maintained in C. elegans reproductive toxicity, but GOs were found to be more toxic in the worms than GNPs. In both systems, SLGO exhibited profoundly greater dose dependency than FLGO. The possible reason of their differential toxicity lay in their distinctive physicochemical characteristics and agglomeration behavior in the exposure media.
Conclusions: The present study revealed that the toxicity of GFNs is dependent on the graphene nanomaterial’s physical forms, surface functionalizations, number of layers, dose, time of exposure and obviously, on the alternative model systems used for toxicity assessment.
Methods: The GFNs used in this study are graphene nanoplatelets ([GNPs]–pristine, carboxylate [COOH] and amide [NH2]) and graphene oxides (single layer [SLGO] and few layers [FLGO]). The human bronchial epithelial cells (Beas2B cells) as in vitro system and the nematode Caenorhabditis elegans as in vivo system were used to profile the toxicity response of GFNs. Cytotoxicity assays, colony formation assay for cellular toxicity and reproduction potentiality in C. elegans were used as end points to evaluate the GFNs’ toxicity.
Results: In general, GNPs exhibited higher toxicity than GOs in Beas2B cells, and among the GNPs the order of toxicity was pristine>NH2>COOH. Although the order of toxicity of the GNPs was maintained in C. elegans reproductive toxicity, but GOs were found to be more toxic in the worms than GNPs. In both systems, SLGO exhibited profoundly greater dose dependency than FLGO. The possible reason of their differential toxicity lay in their distinctive physicochemical characteristics and agglomeration behavior in the exposure media.
Conclusions: The present study revealed that the toxicity of GFNs is dependent on the graphene nanomaterial’s physical forms, surface functionalizations, number of layers, dose, time of exposure and obviously, on the alternative model systems used for toxicity assessment.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (18)
참고문헌 신청
Bianco A / 2013 / Graphene : safe or toxic? The two faces of the medal / Angew Chem Int Ed Engl 52(19):4986~4997
Jastrzębska AM. / 2012 / Recent advances in graphene family materials toxicity investigations / J Nanopart Res 14(12):1320
Sanchez VC. / 2012 / Biological interactions of graphene-family nanomaterials : an interdisciplinary review / Chem Res Toxicol 25(1):15~34
Chung C. / 2013 / Biomedical applications of graphene and graphene oxide / Acc Chem Res 46(10):2211~2224
Novoselov KS. / 2012 / A roadmap for graphene / Nature 490(7419):192~200
Jastrzębska AM. / 2012 / Recent advances in graphene family materials toxicity investigations / J Nanopart Res 14(12):1320
Sanchez VC. / 2012 / Biological interactions of graphene-family nanomaterials : an interdisciplinary review / Chem Res Toxicol 25(1):15~34
Chung C. / 2013 / Biomedical applications of graphene and graphene oxide / Acc Chem Res 46(10):2211~2224
Novoselov KS. / 2012 / A roadmap for graphene / Nature 490(7419):192~200
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UCI(KEPA) : I410-ECN-0101-2017-539-000798857