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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 239 - 253 (15page)
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이 논문의 연구 히스토리 (5)
2017
Twenty-Eight-Day Repeated Inhalation Toxicity Study of Nano-Sized Neodymium Oxide in Male Sprague-Dawley Rats
Yong-Soon Kim
,
Cheol-Hong Lim
,
Seo-Ho Shin
외 1명
Toxicological Research
2017.06
학술저널
Effects of Didecyldimethylammonium Chloride (DDAC) on Sprague-Dawley Rats after 13 Weeks of Inhalation Exposure
Yong-Soon Kim
,
Sung-Bae Lee
,
Cheol-Hong Lim
Toxicological Research
2017.01
학술저널
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초록· 키워드
오류제보하기
Neodymium is a future-oriented material due to its unique properties, and its use is increasing in various industrial fields worldwide. However, the toxicity caused by repeated exposure to this metal has not been studied in detail thus far. The present study was carried out to investigate the potential inhalation toxicity of nano-sized neodymium oxide (Nd<SUB>2</SUB>O<SUB>3</SUB>) following a 28-day repeated inhalation exposure in male Sprague-Dawley rats. Male rats were exposed to nano-sized Nd<SUB>2</SUB>O<SUB>3</SUB>-containing aerosols via a nose-only inhalation system at doses of 0 mg/m<SUP>3</SUP>, 0.5 mg/m<SUP>3</SUP>, 2.5 mg/m<SUP>3</SUP>, and 10 mg/m<SUP>3</SUP> for 6 hr/day, 5 days/week over a 28-day period, followed by a 28-day recovery period. During the experimental period, clinical signs, body weight, hematologic parameters, serum biochemical parameters, necropsy findings, organ weight, and histopathological findings were examined; neodymium distribution in the major organs and blood, bronchoalveolar lavage fluid (BALF), and oxidative stress in lung tissues were analyzed. Most of the neodymium was found to be deposited in lung tissues, showing a dose-dependent relationship. Infiltration of inflammatory cells and pulmonary alveolar proteinosis (PAP) were the main observations of lung histopathology. Infiltration of inflammatory cells was observed in the 2.5 mg/m<SUP>3</SUP> and higher dose treatment groups. PAP was observed in all treatment groups accompanied by an increase in lung weight, but was observed to a lesser extent in the 0.5 mg/m<SUP>3</SUP> treatment group. In BALF analysis, total cell counts, including macrophages and neutrophils, lactate dehydrogenase, albumin, interleukin-6, and tumor necrosis factor-alpha, increased significantly in all treatment groups. After a 4-week recovery period, these changes were generally reversed in the 0.5 mg/m<SUP>3</SUP> group, but were exacerbated in the 10 mg/m<SUP>3</SUP> group. The lowest-observed-adverse-effect concentration of nano-sized Nd<SUB>2</SUB>O<SUB>3</SUB> was determined to be 0.5 mg/m<SUP>3</SUP>, and the target organ was determined to be the lung, under the present experimental conditions in male rats.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
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임경택 / 2013 / Toxicological Evaluations of Rare Earths and Their Health Impacts to Workers: A Literature Review / Safety and Health at Work 4(1):12~26
Raymond, D.H. / 2015 / Hamilton & Hardy’s Industrial Toxicology / John Wiley & Sons :199~204
Haque N / 2014 / Rare Earth Elements:Overview of Mining, Mineralogy, Uses, Sustainability and Environmental Impact / Resources 3(4):614~635
Sabbioni, E / 1982 / ng-term occupational risk of rare-earth pneumoconiosis. A case report as investigated by neutron activation analysis / Sci. Total Environ 26:19~32
임경택 / 2013 / Toxicological Evaluations of Rare Earths and Their Health Impacts to Workers: A Literature Review / Safety and Health at Work 4(1):12~26
Raymond, D.H. / 2015 / Hamilton & Hardy’s Industrial Toxicology / John Wiley & Sons :199~204
Haque N / 2014 / Rare Earth Elements:Overview of Mining, Mineralogy, Uses, Sustainability and Environmental Impact / Resources 3(4):614~635
Sabbioni, E / 1982 / ng-term occupational risk of rare-earth pneumoconiosis. A case report as investigated by neutron activation analysis / Sci. Total Environ 26:19~32
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UCI(KEPA) : I410-ECN-0101-2018-513-001055191