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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 343 - 354 (12page)
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이 논문의 연구 히스토리 (5)
2017
Twenty-Eight-Day Repeated Inhalation Toxicity Study of Nano-Sized Neodymium Oxide in Male Sprague-Dawley Rats
Yong-Soon Kim
,
Cheol-Hong Lim
,
Seo-Ho Shin
외 1명
Toxicological Research
2017.06
학술저널
Effects of Didecyldimethylammonium Chloride (DDAC) on Sprague-Dawley Rats after 13 Weeks of Inhalation Exposure
Yong-Soon Kim
,
Sung-Bae Lee
,
Cheol-Hong Lim
Toxicological Research
2017.01
학술저널
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초록· 키워드
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Aluminum oxide nanoparticles (Al₂O₃ NPs) are among the most widely used nanomaterials; however, relatively little information about their risk identification and assessment is available. In the present study, we aimed to investigate the potential toxicity of Al₂O₃ NPs following repeated inhalation exposure in male Sprague-Dawley rats. Rats were exposed to Al₂O₃ NPs for 28 days (5 days/week) at doses of 0, 0.2, 1, and 5 ㎎/㎥ using a noseonly inhalation system. During the experimental period, we evaluated the clinical signs, body weight change, hematological and serum biochemical parameters, necropsy findings, organ weight, and histopathology findings. Additionally, we analyzed the bronchoalveolar lavage fluid (BALF), including differential leukocyte counts, and aluminum contents in the major organs and blood. Aluminum contents were the highest in lung tissues and showed a dose-dependent relationship in the exposure group. Histopathology showed alveolar macrophage accumulation in the lungs of rats in the 5 ㎎/㎥ group during exposure and recovery. These changes tended to increase at the end of the recovery period. In the BALF analysis, total cell and neutrophil counts and lactate dehydrogenase, tumor necrosis factor-α, and interleukin-6 levels significantly increased in the 1 and 5 ㎎/㎥ groups during exposure. Under the present experimental conditions, we suggested that the no-observed-adverse-effect level of Al₂O₃ NPs in male rats was 1 mg/m3, and the target organ was the lung.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (2)
참고문헌 신청
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UCI(KEPA) : I410-ECN-0101-2018-513-003589381