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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 113 - 118 (6page)
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초록· 키워드
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Ginsan, a botanic polysaccharide extracted from Panax ginseng, has recently been reported to modulate mucosal immune response. In this study, we investigated the protective effect of Ginsan against fatal Vibrio vulnificus mucosal infection. A lethal dose of V. vulnificus (1.0 × 10? CFU/mouse) was nasally inoculated to mice. The bacterial count in the nasal associated lymphoid tissue (NALT) of the mouse was significantly reduced in the Ginsan-treated group. The Ginsan-treated group showed improved survival compared to the control group (100% vs 18%). To elucidate the effect of Ginsan on modulating host immune response, cytokine mRNA expressions involved in mediating inflammation were determined by semiquantitative RT-PCR in the NALTs of the infected mice. Most of the cytokine mRNAs were similarly expressed as the control group. However, COX-1 mRNA expression level was higher in Ginsan-treated group compared to the control group. The protective effect of Ginsan was antagonized by treating with a specific COX-1 inhibitor, SC-560. Thus, these data suggest that the protective effect of Ginsan against V. vulnificus infection is partly mediated by modulating COX-1 expression.
목차
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Tzianabos AO / 2000 / Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function / Clin Microbiol Rev 13 : 523 ~ 533
2. [학술지(정기간행물)] - Wasser SP / 2002 / Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides / Appl Microbiol Biotechnol 60 : 258 ~ 274
3. [학술지(정기간행물)] - Xiang YZ / 2008 / A com- parison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials / Phytother Res 22 : 851 ~ 858
4. [단행본] - Robbers JE / 1999 / Tyler's Herbs of choice: the therapeutic use of phytomedicinals / Haworth Herbal Press
5. [학술지(정기간행물)] - Song JY / 2002 / Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan / Int Immunopharmacol 2 : 857 ~ 865
2. [학술지(정기간행물)] - Wasser SP / 2002 / Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides / Appl Microbiol Biotechnol 60 : 258 ~ 274
3. [학술지(정기간행물)] - Xiang YZ / 2008 / A com- parison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials / Phytother Res 22 : 851 ~ 858
4. [단행본] - Robbers JE / 1999 / Tyler's Herbs of choice: the therapeutic use of phytomedicinals / Haworth Herbal Press
5. [학술지(정기간행물)] - Song JY / 2002 / Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan / Int Immunopharmacol 2 : 857 ~ 865
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The protective role of the polysaccharide Ginsan against Staphylococcus aureus : induction of NO and reduction of poinflammatory cytokines
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Immunostimulating Effects of Polysaccharides of Panax ginseng by Oral Administration into BALB/c Mice
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The modulating activity of Ginsan on radiation-induced disturbance of antioxidant defense systems
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COX-2 억제제의 구조-활성
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소아의 재발성 편도염 조직에서 사이토카인과cyclooxygenase 발현 조절에 관한 연구
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경구투여한 V. vulnificus 백신의 면역원성 및 감염방어효능
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Destructive Intestinal Translocation of Vibrio vulnificus Determines Successful Oral Infection
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TGF-β Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells
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Isolation of Vibrio vulnificus from Seawater and Emerging Vibrio vulnificus Septicemia on Jeju Island
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유방암 조직의 Cox-2 발현
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인간 자궁내막에서 Cyclooxygenase-1과 -2의 주기적 발현 양상
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부검을 통해 확진된 비브리오 불니피쿠스(Vibrio vulnificus) 패혈증 1예
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2009 .01
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Expression of Cyclooxygenase-2 and its Relationship to p53 Accumulation in Colorectal Cancers
Yonsei Medical Journal
2007 .01
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2001년 국내 해양환경에서 분리된 Vibrio vulnificus의 생화학적 특성 및 항생제 감수성 패턴
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2003 .12
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