지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 194 - 200 (7page)
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초록· 키워드
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Ginsan, polysaccharide isolated from the root of Panax ginseng C.A. Meyer, has been shown to be a potent immunomodulator, producing several cytokines and stimulating lymphoid cells to proliferate. In this study, ginsan was orally inoculated into BALB/c mice up to 39 days and the activity of immune cells containing macrophages and T cells was analyzed. Moreover, the production of cytokines, e.g., tumor necrotic factor-α (TNF-α), interferon-γ (IFN-γ), GM-CSF and IL-12 was also analyzed. In results, the phagocytosis of macrophages was increased. About 13% cytotoxicity of NK cells was observed in 22 days and 29 days of administration. But, oral administration did not highly affect the proliferation of T cells. In cytokine analysis, 150 mg/kg and 300 mg/kg at 22 days and 29 days showed three times more increase in TNF-α than the controls. IFN-γ showed 1.07 and 1.16 times more increase at 150 mg/kg and 300 mg/kg over 22 days, respectively more than the controls. 32 days of 150 mg/kg and 300 mg/kg induced GM-CSF of about 1.3 times more than the controls. IL-12 was not induced in samples more than the controls. Ginsan could be a potential immunostimulator. Therefore, our study suggests that it can be adapted as an immunostimulator that requires a relatively short oral administration.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Ahn JY / 2011 / The inhibitory effect of ginsan on TGF-β mediated fibrotic process / J Cell Physiol 226 : 1241 ~ 1247
2. [학술지(정기간행물)] - Ivanova T / 2006 / Antimutagenic effect of polysaccharide ginsan extracted from Panax ginseng / Food Chem Toxicol 44 : 517 ~ 521
3. [학술지(정기간행물)] - Jeong SR / 2005 / Expression of the nfa1 gene cloned from pathogenic Naegleria fowleri in nonpathogenic N. gruberi enhances cytotoxicity against CHO target cells in vitro / Infect Immun 73 : 4098 ~ 4105
4. [학술지(정기간행물)] - Jung SY / 2007 / The capsule plays an important role in Escherichia coli K1 interactions with Acanthamoeba / Int J Parasitol 37 : 417 ~ 423
5. [학술지(정기간행물)] - Kim KH / 1998 / Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2 / Planta Med 64 : 110 ~ 115
2. [학술지(정기간행물)] - Ivanova T / 2006 / Antimutagenic effect of polysaccharide ginsan extracted from Panax ginseng / Food Chem Toxicol 44 : 517 ~ 521
3. [학술지(정기간행물)] - Jeong SR / 2005 / Expression of the nfa1 gene cloned from pathogenic Naegleria fowleri in nonpathogenic N. gruberi enhances cytotoxicity against CHO target cells in vitro / Infect Immun 73 : 4098 ~ 4105
4. [학술지(정기간행물)] - Jung SY / 2007 / The capsule plays an important role in Escherichia coli K1 interactions with Acanthamoeba / Int J Parasitol 37 : 417 ~ 423
5. [학술지(정기간행물)] - Kim KH / 1998 / Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2 / Planta Med 64 : 110 ~ 115
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UCI(KEPA) : I410-ECN-0101-2016-510-001024191