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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 39 - 46 (8page)
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It has been reported that inflammatory diseases such as pneumonitis, retinitis, and hepatitis are associated with human cytomegalovirus (HCMV). Intercellular adhesion molecule (ICAM)-1 is an important inflammatory mediator, helping monocytes adhere to endothelial cells when tissues are infected by pathogen including the HCMV. However, little is known about the mechanism of ICAM-1 stimulation by the HCMV infection in monocytes. In this study, a monocytic cell line THP-1 was used to understand ICAM-1 expression by the HCMV infection. Flow cytometric analyses demonstrated that ICAM-1 was stimulated by the HCMV in THP-1 cells with maximum at 24 hours post infection. The stimulated ICAM-1 expression was dependent on the amount of input virus. In order to understand the mechanism of ICAM-1 stimulation during the HCMV infection, cells were treated with specific inhibitors of key elements in inflammation: NF-κB inhibitor PDTC, cyclooxygenase 2 inhibitor NS398, and MEK inhibitor PD98059. Flow cytometric analyses revealed that ICAM-1 expression was decreased when treated with PDTC, but not with NS398 or PD98059. Thus, it is suggested that HCMV-induced ICAM-1 expression in THP-1 cells is associates with NF-κB.
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재료 및 방법
결과
고찰
참고문헌
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Bolovan-Fritts CA / 1999 / Peripheral blood CD14(+) cells from healthy subjects carry a circular conformation of latent cytomegalovirus genome / Blood 93 : 394 ~ 398
2. [학술지(정기간행물)] - Caposio P / 2004 / Human cytomegalovirus stimulates cellular IKK2 activity and requires the enzyme for productive replication / J Virol 78 : 3190 ~ 3195
3. [학술지(정기간행물)] - Chan G / 2008 / Transcriptome analysis of NF-kappaB- and phosphatidylinositol 3-kinase-regulated genes in human cytomegalovirus-infected monocytes / J Virol 82 : 1040 ~ 1046
4. [학술지(정기간행물)] - Chan G / 2004 / Human cytomegalovirusinduced upregulation of intercellular cell adhesion molecule-1 on vilous syncytiotrophoblasts / Biol Reprod 71 : 797 ~ 803
5. [학술지(정기간행물)] - Chen J / 2002 / Role of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression / J Virol 76 : 4873 ~ 4885
2. [학술지(정기간행물)] - Caposio P / 2004 / Human cytomegalovirus stimulates cellular IKK2 activity and requires the enzyme for productive replication / J Virol 78 : 3190 ~ 3195
3. [학술지(정기간행물)] - Chan G / 2008 / Transcriptome analysis of NF-kappaB- and phosphatidylinositol 3-kinase-regulated genes in human cytomegalovirus-infected monocytes / J Virol 82 : 1040 ~ 1046
4. [학술지(정기간행물)] - Chan G / 2004 / Human cytomegalovirusinduced upregulation of intercellular cell adhesion molecule-1 on vilous syncytiotrophoblasts / Biol Reprod 71 : 797 ~ 803
5. [학술지(정기간행물)] - Chen J / 2002 / Role of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression / J Virol 76 : 4873 ~ 4885
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