Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors

Yilmaz, Umit; Zeybek, Umit; Kahraman, Ozlem Timirci; Kafadar, Ali Metin; Toptas, Bahar; Yamak, Nesibe; Celik, Faruk; Yaylim, Ilhan

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자료유형: 학술저널

저자정보: Yilmaz, Umit (Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University) Zeybek, Umit (Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University) Kahraman, Ozlem Timirci (Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University) Kafadar, Ali Metin (Department of Neurosurgery, Cerrahpasa Faculty of Medicine, Istanbul University) Toptas, Bahar (Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University) Yamak, Nesibe (Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University) Celik, Faruk (Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University) Yaylim, Ilhan (Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제10호

발행연도: 2013.1

수록면: 5,929 - 5,934 (6page)

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Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. ${\beta}3$ integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and ITGB3 could be associated with brain cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between brain tumor risk and ICAM-1 and ${\beta}3$ integrin gene polymorphisms. Materials and Methods: The study covered 92 patients with primary brain tumors and 92 age-matched healthy control subjects. Evaluation of ${\beta}3$ integrin (Leu33Pro (rs5918)) and ICAM-1 (R241G (rs1799969) and K469E (rs5498)) gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: According to results of our research, the A allele of the ICAM-1 R241G gene polymorphism appeared to be a risk factor for primary brain tumors (p<0.001). Similarly, the frequency of the A mutant allele of ICAM-1 R241G was statistically significant in patients with brain tumors classified as glioma (p<0.001). When allele and genotype distributions of ICAM-1 K469E, ICAM-1 R241G and ${\beta}3$ integrin Leu33Pro gene polymorphisms were evaluated with age, sex, and smoking, there were no statistically significant differences. Haplotype analysis revealed that the frequencies of GAC (rs1799969-rs5498-rs5918) and GAT (rs1799969-rs5498-rs5918) haplotypes were significantly lower in patients as compared with controls (p=0.001; p=0.036 respectively). Conclusions: This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. In addition, our results suggest that ICAM-1 R241G in combination ICAM-1 K469E may have protective effects against the development of brain cancer.

#Cancer #brain tumor #polymorphism #ICAM-1 #${beta}3$-integrin

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Yilmaz, Umit

소속기관 The Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University