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자료유형
학술저널
저자정보
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제7권 제1호
발행연도
1977.6
수록면
31 - 39 (9page)

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Epidemic hemorrhagic fever was recognized for the first time in Korea in 1951 among United Nations soldiers. Since that time it has been known as Korean hemorrhagic fever (KHF) and has remained endemic near the demilitarized zone between North and South Korea. In recent years it appears to have spread slowly in a southwesterly direction and 100 to 800 hospitalized cases are clinically diagnosed each year. In 1976 Lee and Lee succeeded in demonstrating an antigen in the lungs of the striped field mouse, Apodemus agrarius, which gave specific immunofluorescent reactions with sera of patients convalescent from KHF for the first time. In 1977 Lee and Lee reported that the antigen is the etiologic agent of KHF and was successfully propagated in Apodemus through 13 passages. The agent is a small virus, was neutralized with convalescent serum of KHF patient, chloroform sensitive and passed through 0.1 p filter. 1t is proved that the reservoir of KHF in endemic areas is Apodemus agrarius coreae by isolation of 73 strains of KHF virus from 1974 to 1977 for the first time. Incubation period was 9 days in Apodemus after KHF virus inoculation and infection of the virus lasted over 2 months. Attempts to grow the KHF agent in laboratory animals and field rodents other than Apodemus were failed.

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