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자료유형
학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제11권 제1호
발행연도
1981.6
수록면
13 - 19 (7page)

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The effects of virazole to Hantaan virus, the causative agent of Korean hemorrhagic fever (KHF), were observed in the experiments in vivo of Apodemus agrarius coreae, the reservoir of KHF in the rural endemic areas of Korea. The following results were obtained. 1. When intramuscular injection of virazole was done, up to 50,ug/kg/day in amount for a few days, relative toxic effects were observed. And when 25 ug/kg/day was injected intramuscularly for several days, no specific toxic effects were observed. 2. After injection of Hantaan virus into Apodemus agrarius coreae, the virus proliferation was suppressed by consecutive injection of virazole right after inoculation of the virus for 5 days. 3. Since Apodemus agrarius coreae had no clinical symptoms despite of Hantaan viral multiplication, the effects of virazole to the course of illness and symptoms were not able to detect. Above results showed that some preventive pharmacological effects of virazole on Hantaan virus infection in vertebrate were suspected by demonstration of inhibition of virus multiplication after injection of virazole into infected Apodemus agrarius coreae on appropriate timing.

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