Anti-leishmanial Effects of Trinitroglycerin in BALB/C Mice Infected with Leishmania major via Nitric Oxide Pathway

Hossein Nahrevanian; Mana Najafzadeh; Reza Hajihosseini; Habib Nazem; Mahin Farahmand; Zahra Zamani

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자료유형: 학술저널

저자정보: Hossein Nahrevanian (Pasteur Institute of Iran) Mana Najafzadeh (Payame Nour University) Reza Hajihosseini (Payame Nour University) Habib Nazem (Payame Nour University) Mahin Farahmand (Pasteur Institute of Iran) Zahra Zamani (Pasteur Institute of Iran)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.47 No.2

발행연도: 2009.6

수록면: 109 - 115 (7page)

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This study investigated whether trinitroglycerine (TNG) as nitric oxide (NO) releasing agent had anti-leishmanial effects and mediated pathology in BALB/c mice infected with Leishmania major. Cutaneous leishmaniasis (CL), a zoonotic infection caused by leishmania protozoa is still one of the health problems in the world and in Iran. NO is involved in host immune responses against intracellular L. major, and leishmania killing by macrophages is mediated by this substance. Moreover, application of CL treatment with NO-donors has been recently indicated. In our study, TNG was used for its ability to increase NO and to modify CL infection in mice, in order to evaluate NO effects on lesion size and formation, parasite proliferation inside macrophages, amastigote visceralization in target organs, and NO induction in plasma and organ suspensions. Data obtained in this study indicated that TNG increased plasma and liver-NO, reduced lesion sizes, removed amastigotes from lesions, livers, spleens, and lymph nodes, declined proliferation of amastigotes, hepatomegaly, and increased survival rate. However, TNG reduced spleen-NO and had no significant effects on spelenomegaly. The results show that TNG therapy reduced leishmaniasis and pathology in association with raised NO levels. TNG had some antiparasitic activity by reduction of positive smears from lesions, livers, spleens, and lymph nodes, which could emphasize the role of TNG to inhibit visceralization of L. major in target organs.

#Leishmania major #BALB/c mouse #nitric oxide #trinitroglycerin #Iran

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