The Route of Leishmania tropica Infection Determines Disease Outcome and Protection against Leishmania major in BALB/c Mice

Hamid Mahmoudzadeh-Niknam; Ghader Khalili; Firoozeh Abrishami; Ali Najafy; Vahid Khaze

추천

검색

질문

자료유형: 학술저널

저자정보: Hamid Mahmoudzadeh-Niknam (Pasteur Institute of Iran) Ghader Khalili (Pasteur Institute of Iran) Firoozeh Abrishami (Pasteur Institute of Iran) Ali Najafy (Pasteur Institute of Iran) Vahid Khaze (Pasteur Institute of Iran)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.51 No.1

발행연도: 2013.2

수록면: 69 - 74 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Leishmania tropica is one of the causative agents of leishmaniasis in humans. Routes of infection have been reported to be an important variable for some species of Leishmania parasites. The role of this variable is not clear for L. tropica infection. The aim of this study was to explore the effects of route of L. tropica infection on the disease outcome and immunologic parameters in BALB/c mice. Two routes were used; subcutaneous in the footpad and intradermal in the ear. Mice were challenged by Leishmani major, after establishment of the L. tropica infection, to evaluate the level of protective immunity. Immune responses were assayed at week 1 and week 4 after challenge. The subcutaneous route in the footpad in comparison to the intradermal route in the ear induced significantly more protective immunity against L. major challenge, including higher delayed-type hypersensitivity responses, more rapid lesion resolution, lower parasite loads, and lower levels of IL-10. Our data showed that the route of infection in BALB/c model of L. tropica infection is an important variable and should be considered in developing an appropriate experimental model for L. tropica infections.

#Leishmania tropica #Leishmania major #intradermal #subcutaneous #immunity #disease outcome

참고문헌 (22)

참고문헌 신청

1. [보고서] - World Health Organization / 2010 / Control of the Leishmaniases: Report of a Meeting of the WHO Expert Committee on the Control of Leishmaniases

2. [학술지(정기간행물)] - Hamid Mahmoudzadeh-Niknam / 2007 / Viscerotropic growth pattern of Leishmania tropica in BALB/c mice is suggestive of a murine model for human viscerotropic leishmaniasis / The Korean Journal of Parasitology 45 (4) : 247 ~ 253

3. [학술지(정기간행물)] - Lira R / 1998 / Leishmania tropica: the identification and purification of metacyclic promastigotes and use in establishing mouse and hamster models of cutaneous and visceral disease / Exp Parasitol 89 : 331 ~ 342

4. [학술지(정기간행물)] - Sacks D / 2002 / The immunology of susceptibility and resistance to Leishmania major in mice / Nat Rev Immunol 2 : 845 ~ 858

5. [학술지(정기간행물)] - Hamid Mahmoudzadeh-Niknam / 2007 / Leishmania tropica infection, in comparison toLeishmania major, induces lower delayed type hypersensitivityin BALB/c mice / The Korean Journal of Parasitology 45 (2) : 103 ~ 109