지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 173 - 183 (11page)
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Purpose: Recent findings indicate that after cholecystectomy for early gallbladder cancer (GBC), outcomes are generally satisfactory. But outcomes for advanced GBC are dismal, even with recent advances in diagnostic and therapeutic modalities. The purpose of this study was to evaluate surgical outcomes and prognostic factors affecting survival after surgical resection in patients with GBC.
Methods: We retrospectively reviewed clinical data from 133 patients with GBC who underwent surgical resection between January 2000 and December 2008. Their clinical condition, surgical treatment, and pathologic factors were analyzed.
Results: Among the 133 patients with GBC, curative resection was achieved in 95 (71.4%). The 5-year survival rate in patients who underwent curative resection (52.6%) was much better than in those who underwent palliative resection (0.0%, p＜0.000). Univariate analysis revealed that the following factors were associated with patient survival: preoperative jaundice, pain at presentation, incidental GBC, serum total bilirubin, alkaline phosphatase (ALP), carbohydrate antigen 19-9 levels, curability, lymph node (LN) dissection, size, site, macroscopic type of tumor, histologic differentiation, the depth of tumor invasion (T stage), LN metastasis, TNM stage and microscopic perineural invasion. Multivariate analysis revealed that the following were independent, favorable prognostic factors: curative resection, no LN metastasis, low TNM stage, non-papillary macroscopic type, and low ALP levels.
Conclusion: Complete tumor resection and no LN metastasis are important prognostic factors for GBC. Favorable survival outcomes can be achieved when curative resection is done in early stage GBC and when operative procedures are planned with the consideration of the survival benefit of surgery in advanced GBC.
Methods: We retrospectively reviewed clinical data from 133 patients with GBC who underwent surgical resection between January 2000 and December 2008. Their clinical condition, surgical treatment, and pathologic factors were analyzed.
Results: Among the 133 patients with GBC, curative resection was achieved in 95 (71.4%). The 5-year survival rate in patients who underwent curative resection (52.6%) was much better than in those who underwent palliative resection (0.0%, p＜0.000). Univariate analysis revealed that the following factors were associated with patient survival: preoperative jaundice, pain at presentation, incidental GBC, serum total bilirubin, alkaline phosphatase (ALP), carbohydrate antigen 19-9 levels, curability, lymph node (LN) dissection, size, site, macroscopic type of tumor, histologic differentiation, the depth of tumor invasion (T stage), LN metastasis, TNM stage and microscopic perineural invasion. Multivariate analysis revealed that the following were independent, favorable prognostic factors: curative resection, no LN metastasis, low TNM stage, non-papillary macroscopic type, and low ALP levels.
Conclusion: Complete tumor resection and no LN metastasis are important prognostic factors for GBC. Favorable survival outcomes can be achieved when curative resection is done in early stage GBC and when operative procedures are planned with the consideration of the survival benefit of surgery in advanced GBC.
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참고문헌
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Konstantinidis IT / 2009 / Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience / Arch Surg 144 : 441 ~ 447
2. [학술지(정기간행물)] - Shih SP / 2007 / Gallbladder cancer: the role of laparoscopy and radical resection / Ann Surg 245 : 893 ~ 901
3. [학술지(정기간행물)] - Chan SY / 2008 / Management of carcinoma of the gallbladder: a single-institution experience in 16 years / J Surg Oncol 97 : 156 ~ 164
4. [학술지(정기간행물)] - Piehler JM / 1978 / Primary carcinoma of the gallbladder / Surg Gynecol Obstet 147 : 929 ~ 942
5. [학술지(정기간행물)] - Cubertafond P / 1994 / Surgical treatment of 724 carcinomas of the gallbladder. Results of the French Surgical Association Survey / Ann Surg 219 : 275 ~ 280
2. [학술지(정기간행물)] - Shih SP / 2007 / Gallbladder cancer: the role of laparoscopy and radical resection / Ann Surg 245 : 893 ~ 901
3. [학술지(정기간행물)] - Chan SY / 2008 / Management of carcinoma of the gallbladder: a single-institution experience in 16 years / J Surg Oncol 97 : 156 ~ 164
4. [학술지(정기간행물)] - Piehler JM / 1978 / Primary carcinoma of the gallbladder / Surg Gynecol Obstet 147 : 929 ~ 942
5. [학술지(정기간행물)] - Cubertafond P / 1994 / Surgical treatment of 724 carcinomas of the gallbladder. Results of the French Surgical Association Survey / Ann Surg 219 : 275 ~ 280
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UCI(KEPA) : I410-ECN-0101-2014-514-001000284