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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제18권 제1호
발행연도
2012.1
수록면
48 - 88 (41page)

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Background/Aims: Hepatocellular carcinoma (HCC), which is the third most common cancer in Korea, has a very poor prognosis. However, only a few studies have performed a comprehensive survival-related analysis in all patients who were consecutively diagnosed and treated over a given period of time. The aim of this study was to determine the 5-year survival rate and its prognostic factors among HCC patients. Methods: In total, 257 patients who were consecutively diagnosed with HCC between January 2000 and December 2003 were followed until death or until December 2008. We analyzed their survival outcomes according to their clinical characteristics, tumor staging, and treatment modalities, and determined the independent prognostic factors affecting survival. Results: The patients were aged 59±10 years (mean±SD). During the follow-up period, 223 patients (86.8%) died and the overall median survival was 10.8 months; the 1-, 3-, and 5-year survival rates were 44.4%, 21.0%, and 12.1%, respectively. The outcomes in patients with tumor node metastasis (TNM) stage I or II and Child-Pugh class A or B were significantly better with surgical resection than with other treatment modalities (P<0.01). Patients who underwent supplementary transcatheter arterial chemoembolization as a second-line treatment after surgical resection had better outcomes than those who underwent surgical resection alone (P=0.02). Initial symptoms, Child-Pugh class, serum alpha-fetoprotein, tumor size, portal vein thrombosis, and TNM stage were found to be independent prognostic factors for survival among HCC patients. Conclusions: This retrospective cohort study elucidated survival outcomes and prognostic factors affecting survival in HCC patients at a single center. (Korean J Hepatol 2012;18:48-55)
#Hepatocellular carcinoma #Survival #Prognosis #Treatment #Tumor staging

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참고문헌 (25)

참고문헌 신청
Capocaccia R / 2007 / Hepatocellular carcinoma: trends of incidence and survival in Europe and the United States at the end of the 20th century / Am J Gastroenterol 102 : 166 google schola Kanematsu T / 2002 / A 16-year experience in performing hepatic resection in 303 patients with hepatocellular carcinoma: 1985-2000 / Surgery 131 (Suppl) : S153 ~ S158 google schola Korea National Statistical Office / 2006 / Annual report on the cause of death statistics 2005 : 6 ~ 15 google schola Kyu-Won Jung / 2007 / Cancer Survival in Korea 1993-2002: A Population-Based Study / Journal of Korean Medical Science 22 (S) : 5 ~ 10 google schola Lee CS / 1996 / Long-term outcome after surgery for asymptomatic small hepatocellular carcinoma / Br J Surg 83 : 330 ~ 333 google schola

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