지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.87 No.4
- 발행연도
- 2014.9
- 수록면
- 180 - 184 (5page)
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초록· 키워드
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Purpose: The evaluation and extent of lymph node (LN) retrieval is clinically relevant for staging because lymphatic invasion is the most common mechanism leading to up-staging of carcinoma. However, the optimal number of LN retrievals for early gastric cancer (EGC) is unclear. With the aim of clarification, we analyzed our database to investigate the optimal number of retrieved LNs in EGC.
Methods: Three hundred twenty-six gastric cancer patients who underwent curative gastrectomy with D2 LN dissection at Ewha Womans University Hospital (Dongdaemun and Mokdong) were analyzed according to sex, age, tumor location, size of tumor, macroscopic type, histological classification, depth of invasion, LNs metastasis, TNM stage and type of surgery.
Results: In LN negative cases, patients with 15?25 retrieved LNs had a 5- and 10-year survival rate of 88% and 54%, respectively, whereas retrieval of ≥26 LNs was associated with 5- and 10-year survival rate of 90% and 75%, respectively (P = 0.105). In LN positive cases, the 5- and 10-year survival rate was 50% and 30% for the 15?25 group, and 77% and 67% for the ≥26 group, respectively (P = 0.044).
Conclusion: LN metastasis is an independent factor of survival and the number of retrieved LNs significantly relate to the long-term survival benefit in node metastatic EGC. Also, our data suggest that the retrieval of at least 15 LNs may not be sufficient to warrant recommendation for more curative surgery, and that qualified LN dissection should be considered if LN metastasis is in doubt, even in EGC.
Methods: Three hundred twenty-six gastric cancer patients who underwent curative gastrectomy with D2 LN dissection at Ewha Womans University Hospital (Dongdaemun and Mokdong) were analyzed according to sex, age, tumor location, size of tumor, macroscopic type, histological classification, depth of invasion, LNs metastasis, TNM stage and type of surgery.
Results: In LN negative cases, patients with 15?25 retrieved LNs had a 5- and 10-year survival rate of 88% and 54%, respectively, whereas retrieval of ≥26 LNs was associated with 5- and 10-year survival rate of 90% and 75%, respectively (P = 0.105). In LN positive cases, the 5- and 10-year survival rate was 50% and 30% for the 15?25 group, and 77% and 67% for the ≥26 group, respectively (P = 0.044).
Conclusion: LN metastasis is an independent factor of survival and the number of retrieved LNs significantly relate to the long-term survival benefit in node metastatic EGC. Also, our data suggest that the retrieval of at least 15 LNs may not be sufficient to warrant recommendation for more curative surgery, and that qualified LN dissection should be considered if LN metastasis is in doubt, even in EGC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Yoshikawa T. / 2006 / Stage migration caused by D2 dissection with para-aortic lymphadenectomy for gastric cancer from the results of a prospective randomized controlled trial / Br J Surg 93 : 1526 ~ 1529
2. [학술지(정기간행물)] - Hundahl SA. / 2002 / Staging, stage migration, and patterns of spread in gastric cancer / Semin Radiat Oncol 12 : 141 ~ 149
3. [학술지(정기간행물)] - Baiocchi GL. / 2010 / A multicentric Western analysis of prognostic factors in advanced, node-negative gastric cancer patients / Ann Surg 252 : 70 ~ 73
4. [학술지(정기간행물)] - Chen XZ. / 2011 / Is retrieval of >25 lymph nodes a superior criterion for locally advanced gastric cancer surgery? / Ann Surg 254 : 834 ~ 835
5. [학술지(정기간행물)] - Smith DD. / 2005 / Impact of total lymph node count on staging and survival after gastrectomy for gastric cancer : data from a large US-population database / J Clin Oncol 23 : 7114 ~ 7124
2. [학술지(정기간행물)] - Hundahl SA. / 2002 / Staging, stage migration, and patterns of spread in gastric cancer / Semin Radiat Oncol 12 : 141 ~ 149
3. [학술지(정기간행물)] - Baiocchi GL. / 2010 / A multicentric Western analysis of prognostic factors in advanced, node-negative gastric cancer patients / Ann Surg 252 : 70 ~ 73
4. [학술지(정기간행물)] - Chen XZ. / 2011 / Is retrieval of >25 lymph nodes a superior criterion for locally advanced gastric cancer surgery? / Ann Surg 254 : 834 ~ 835
5. [학술지(정기간행물)] - Smith DD. / 2005 / Impact of total lymph node count on staging and survival after gastrectomy for gastric cancer : data from a large US-population database / J Clin Oncol 23 : 7114 ~ 7124
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UCI(KEPA) : I410-ECN-0101-2015-510-002857725