지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.8
- 수록면
- 79 - 85 (7page)
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초록· 키워드
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Purpose: Insulin-like growth factor binding protein (IGFBP-3) and phosphatase and tensin homolog (PTEN) are tumor-suppressor genes that may be involved in breast tumorigenesis. However, the roles of these genes in the regulation of breast cancer growth or progress are unclear. In this study, we aimed to find any correlation between the reduction of IGFBP-3 or PTEN protein expression in cancer tissues and the clinicopathological parameters in breast cancer.
Methods: We collected both cancer and adjacent normal tissues from 46 breast cancer patients (from January 1 to December 31, 2006), and checked the IGFBP-3 and PTEN protein levels in cancer and adjacent normal tissues using Western immunoblot. We evaluated the correlation of reduction status of IGFBP-3 and PTEN protein expression with variable clinicopathological parameters.
Results: The frequency of IGFBP-3 and PTEN protein reduction in cancer tissue, compared to adjacent normal tissue, was 63.0% and 34.8%, respectively. And in 87.5% of patients, who showed significant PTEN reduction, IGFBP-3 protein expression was reduced in cancer tissues. In contrast, IGFBP-3 protein reduced in only 50% of patients who didn’t show PTEN reduction. However, we did not find any significant correlation between reduction of IGFBP-3 or PTEN expression in cancer tissue and variable clinicopathological parameters.
Conclusion: The IGFBP-3 and PTEN genes were expressed in all breast cancer tissues. Nonetheless, we did not find any significant relationship between reduction of IGFBP-3 or PTEN expression and the clinicopathological parameters in this study. Therefore, further studies are needed to document the roles of IGFBP-3 and PTEN genes in breast cancer growth or progress.
Methods: We collected both cancer and adjacent normal tissues from 46 breast cancer patients (from January 1 to December 31, 2006), and checked the IGFBP-3 and PTEN protein levels in cancer and adjacent normal tissues using Western immunoblot. We evaluated the correlation of reduction status of IGFBP-3 and PTEN protein expression with variable clinicopathological parameters.
Results: The frequency of IGFBP-3 and PTEN protein reduction in cancer tissue, compared to adjacent normal tissue, was 63.0% and 34.8%, respectively. And in 87.5% of patients, who showed significant PTEN reduction, IGFBP-3 protein expression was reduced in cancer tissues. In contrast, IGFBP-3 protein reduced in only 50% of patients who didn’t show PTEN reduction. However, we did not find any significant correlation between reduction of IGFBP-3 or PTEN expression in cancer tissue and variable clinicopathological parameters.
Conclusion: The IGFBP-3 and PTEN genes were expressed in all breast cancer tissues. Nonetheless, we did not find any significant relationship between reduction of IGFBP-3 or PTEN expression and the clinicopathological parameters in this study. Therefore, further studies are needed to document the roles of IGFBP-3 and PTEN genes in breast cancer growth or progress.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Hai-Rim Shin / 2005 / Nationwide Cancer Incidence in Korea, 1999~2001; First Result Using the National Cancer Incidence Database / Cancer Research and Treatment 37 (6) : 325 ~ 331
2. [학술지(정기간행물)] - Andersen TI / 1996 / Genetic heterogeneity in breast cancer susceptibility / Acta Oncol 35 : 407 ~ 410
3. [학술지(정기간행물)] - Yee D / 1989 / Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer / Mol Endocrinol 3 : 509 ~ 517
4. [학술지(정기간행물)] - Dhar K / 2007 / Insulin-like growth factor-1 (IGF-1) induces WISP-2/CCN5 via multiple molecular cross-talks and is essential for mitogenic switch by IGF-1 axis in estrogen receptor-positive breast tumor cells / Cancer Res 67 : 1520 ~ 1526
5. [학술지(정기간행물)] - Jones JI / 1995 / Insulin-like growth factors and their binding proteins: biological actions / Endocr Rev 16 : 3 ~ 34
2. [학술지(정기간행물)] - Andersen TI / 1996 / Genetic heterogeneity in breast cancer susceptibility / Acta Oncol 35 : 407 ~ 410
3. [학술지(정기간행물)] - Yee D / 1989 / Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer / Mol Endocrinol 3 : 509 ~ 517
4. [학술지(정기간행물)] - Dhar K / 2007 / Insulin-like growth factor-1 (IGF-1) induces WISP-2/CCN5 via multiple molecular cross-talks and is essential for mitogenic switch by IGF-1 axis in estrogen receptor-positive breast tumor cells / Cancer Res 67 : 1520 ~ 1526
5. [학술지(정기간행물)] - Jones JI / 1995 / Insulin-like growth factors and their binding proteins: biological actions / Endocr Rev 16 : 3 ~ 34
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