Prostate Cancer Risk in Relation to a Single Nucleotide Polymorphism in the Insulin-like Growth Factor-binding Protein-3 (IGFBP3) Gene: a Meta-analysis

Mao, Ye-Qing; Xu, Xin; Lin, Yi-Wei; Chen, Hong; Hu, Zheng-Hui; Xu, Xiang-Lai; Zhu, Yi; Wu, Jian; Zheng, Xiang-Yi; Qin, Jie; Xie, Li-Ping

추천

검색

자료유형: 학술저널

저자정보: Mao, Ye-Qing (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Xu, Xin (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Lin, Yi-Wei (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Chen, Hong (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Hu, Zheng-Hui (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Xu, Xiang-Lai (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Zhu, Yi (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Wu, Jian (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Zheng, Xiang-Yi (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Qin, Jie (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University) Xie, Li-Ping (Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang U)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제12호

발행연도: 2012.1

수록면: 6,299 - 6,303 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Insulin-like growth factor-binding protein-3 (IGFBP3) has been identified as a putative tumor suppressor with multifunctional roles in the IGF axis. Recently, there have been a growing body of studies investigating the relation between the IGFBP3 A-202C polymorphism, circulating IGFBP3 and prostate cancer risk, but their outcomes varied leading to controversy. Hence, it is necessary to perform a meta-analysis covering all eligible studies to shed a light on the association of IGFBP3 A-202C and cancer risk. Finally, we included a total of 11 relevant articles between 2003 and 2010 covering 14 case-control studies including 9,238 cases and 8,741 controls for our analysis. Our results showed that A-202C was a marginal risk factor of prostate cancer (allele contrast: OR=1.08, 95% CI :1.01-1.16; dominant model: OR=1.11, 95% CI :1.01-1.22; heterozygote codominant model: OR=1.11, 95% CI :1.03-1.18; homozygote contrast: OR=1.19, 95% CI :1.03-1.37). Stratification analysis revealed that sample size and control source were two major heterogeneous meta-factors especially in the recessive model (source: Population-based control group :p=0.30,I2=16.7%, Hospital-based control group: p=0.20, I2=30.3%; sample size: Small: p=0.22,I2= 32.8%, Medium: p=0.09,I2=48%, Large p=0.60,I2=0.0%); However, contrary to previous findings, no significance was found in racial subgroups. No significant publication bias was found in our analysis. Considering the robustness of the results and the discrepancy among some studies, there might be some unsolved confounding factors, and further more critical large studies are needed for confirmation.

#IGFBP3 #prostate cancer #polymorphism #meta-analysis

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Mao, Ye-Qing

소속기관 Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University