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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 102 - 108 (7page)
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초록· 키워드
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Purpose: The PTEN gene, a novel tumor suppressor,
is localized to chromosome 10q23.3 and shares extensive
homology with the cytoskeletal protein, tensin. A
high frequency of mutations at the PTEN locus has been
described in a variety of neoplasms including breast
cancer and Cowden Disease. However, the role of PTEN
alterations and its association with clinicopathological
factors have not been well established. We investigated
the relationship between the PTEN expression and clinicopathological
factors.
Materials and Methods: Formalin-fixed, paraffin-embedded
tissues from 105 women with breast cancer were
evaluated for the PTEN expression and were scored
semi-quantitatively based on staining intensity and distribution.
Results were statistically compared with clinicopathological
factors.
Results: Forty-seven (45%) of the 105 breast cancers
had a loss of the PTEN expression. In the recurrent group,
19 of 32 (59%) patients showed a loss of the PTEN expression,
whereas in the non-recurrent group, only 28 of 73
(38%) patients showed a loss of the PTEN expression. The
loss of PTEN expression correlated with estrogen receptors
(ER) (p=0.027), recurrence (p=0.046), HER-2/neu
overexpression (p=0.016), disease-free survival (p=0.0163),
and overall survival (p=0.0357). In particular, when HER-2/
neu was overexpressed, the overall survival rate correlated
with the loss of PTEN expression statistically
(p=0.0454), whereas when HER-2/neu was negative, there
was no correlation (p=0.9808). Progesterone receptor (PR)
and disease stage had no relationship with the PTEN
expression.
Conclusion: Our results support that PTEN plays a role
as a tumor suppressor in breast cancer and is a prognostic
factor in predicting recurrence. (Cancer Research
and Treatment 2003;35:102-108)
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Loss of PTEN Expression in Primary Lung Cancer
Journal of Pathology and Translational Medicine
2002 .01
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유방암에서 PTEN 종양 억제인자의 발현과 VEGF 매개성 혈관 생성과의 관계
Journal of Pathology and Translational Medicine
2004 .01
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Loss of PTEN Expression in Breast Cancers
Journal of Pathology and Translational Medicine
2005 .01
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Prognostic Role of PTEN Gene Expression and Length of Survival of Breast Cancer Patients in the North East of Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Prognostic Role of PTEN Gene Expression in Breast Cancer Patients from North-East Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-small Cell Lung Cancer
Journal of Pathology and Translational Medicine
2011 .01
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Sodium Iodide Symporter and Phosphatase and Tensin Homolog Deleted on Chromosome Ten Expression in Cholangiocarcinoma Analysis with Clinicopathological Parameters
Gut and Liver
2012 .01
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Loss of Expression of PTEN is Associated with Worse Prognosis in Patients with Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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침윤성 유방암에서 PTEN 단백 발현과 다른 예후인자들과의 관계
Annals of Surgical Treatment and Research
2004 .04
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폐암 조직에서의 PTEN 발현 정도와 Gefitinib의 반응율과의 관계
Tuberculosis and Respiratory Diseases
2005 .01
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유방암에서 Insulin-like Growth Factor Binding Protein (IGFBP)-3 및 PTEN 발현의 감소와 임상병리학적 소견과의 관련성
Annals of Surgical Treatment and Research
2010 .08
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Over-expression of PTEN Involved in Troglitazone-induced Apoptosis in Human Osteosarcoma Cells
대한골관절종양학회지
2011 .01
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Upregulation of Estrogen Receptor by Tumor Suppressor Protein PTEN in Breast Cancer Cell Line MCF-7 Cells
대한외과학회 학술대회 초록집
2005 .05
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Impact of HER2 and PTEN Simultaneous Deregulation in Non-small Cell Lung Carcinoma: Correlation with Biological Behavior
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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PTEN Methylation Dependent Sinonasal Mucosal Melanoma
Cancer Research and Treatment
2016 .01
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Roles of PTEN (Phosphatase and Tensin Homolog) in Gastric Cancer Development and Progression
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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PTEN Mutation Identified in Patient Diagnosed with Simultaneous Multiple Cancers
Cancer Research and Treatment
2019 .01
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Predictive and Prognostic Significance of p27, Akt, PTEN and PI3K Expression in HER2-Positive Metastatic Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Analysis of PTEN, VEGF, HER2 and P53 Status in Determining Colorectal Cancer Benefit from Bevacizumab Therapy
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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