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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제18권 제1호
- 발행연도
- 2013.1
- 수록면
- 9 - 12 (4page)
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Insulin-like growth factor binding protein (IGFBP)-3 has roles in modulating the effect of IGFs by binding to IGFs and inhibiting cell proliferation in an IGF-independent manner.
Although recent studies have been reported that IGFBP-3 has also roles in metabolic regulation, their exact roles in adipose tissue are poorly understood. In this review, we summarized the studies about the biological roles in glucose and lipid metabolism.
IGFBP-3 overexpression in transgenic mice suggested that IGFBP-3 results in glucose intolerance, and insulin resistance. IGFBP-3 knockout (KO) mice exhibited normal insulin level and glucose response after glucose challenge. More recent study in IGFBP-3 KO mice with a high-fat diet demonstrated that IGFBP-3 KO mice exhibited elevated fasting glucose and insulin, but normal response to glucose challenge, suggesting that IGFBP-3KO mice may induce insulin resistance even though preserved insulin sensitivity. In vitro and in vivo studies using 3T3-L1 adipocytes and rat, IGFBP-3 induced insulin resistance by inhibiting glucose uptake. In contrast, the reduced levels of IGFBP-3 in obesity might induce insulin resistance by suppression of IGFBP-3’s anti-inflammatory function,suggesting IGFBP-3 has a protective effect on insulin resistance. Also, proteolysis of IGFBP-3 might contribute to the insulin resistance in obesity and type 2 diabetes mellitus. In addition, IGFBP-3 inhibited adipocyte differentiation, suggesting IGFBP-3 may contribute to the insulin insensitivity. Taken together, it is not yet certain that IGFBP-3 has a protective effect or enhancing effect on insulin resistance, and more studies will be needed to clarify the roles of IGFBP-3 in metabolic regulation.
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참고문헌 (21)
참고문헌 신청
Blat C / 1989 / Inhibitory diffusible factor 45 bifunctional activity. As a cell growth inhibitor and as an insulin-like growth factor I-binding protein / J Biol Chem 264 : 1
Butt AJ / 2000 / Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breas
Chan SS / 2005 / Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes / J Clin Endocrinol Metab 90 : 6588 ~ 6595
Cohen P / 1993 / Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth / Mol Endocrinol 7 : 380 ~ 386
Firth SM / 2002 / Cellular actions of the insulin-like growth factor binding proteins / Endocr Rev 23 : 824 ~ 854
Butt AJ / 2000 / Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breas
Chan SS / 2005 / Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes / J Clin Endocrinol Metab 90 : 6588 ~ 6595
Cohen P / 1993 / Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth / Mol Endocrinol 7 : 380 ~ 386
Firth SM / 2002 / Cellular actions of the insulin-like growth factor binding proteins / Endocr Rev 23 : 824 ~ 854
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