지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제2호
- 발행연도
- 2004.1
- 수록면
- 100 - 105 (6page)
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초록· 키워드
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Background : PTEN is a novel tumor suppressor gene located at chromosome 10q23.3.
Loss of PTEN function has been implicated in the progression of several types of cancer.
Angiogenesis is a critical factor in tumor growth and metastasis. We investigated PTEN
expression in invasive breast cancers and described its role in the regulation of angiogenesis
related to vascular endothelial growth factor (VEGF). Methods : Forty-five, surgically resected,
formalin-fixed and paraffin embedded breast cancer tissue samples were analyzed for
PTEN and VEGF expressions by immunohistochemistry and for microvessel density (MVD)
by CD34 immunostaining. Results : Loss of PTEN expression was found in 35.6% (16/45)
of the breast cancer tissues, all of which showed positive VEGF expression. Among 29
cases with normal PTEN expression, 15 (51.7%) were VEGF positive. MVD was significantly
higher in tumors with a loss of PTEN expression than in those with normal PTEN expression.
Conclusion : A loss of PTEN expression might increase the VEGF-related angiogenesis in
breast cancer. There was no correlation between PTEN expression and clinicopathologic
parameters. Detection of the loss of PTEN expression may serve as a useful biologic marker
for progression in invasive breast cancer.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ 1991 / Pathological prognostic factors in breast cancer .I. The value of histological grade in breast cancer experiencefrom a large study with long-term follow-up : 403 ~
/ 1993 / Tumorangiogenesis correlates with metastasis in invasive prostate carcinoma 143 : 401 ~ 409
/ 1995 / Allelic loss of sequences from the long arm of chromosome10 and replicaton errors in endometrial cancers 55 : 1922 ~ 1926
/ 1995 / Loss of chromosomal region 10q23-25 in prostate cancer 55 : 4800 ~ 4803
/ 1996 / How tumors become angiogenic. 69 : 135 ~ 174
/ 1993 / Tumorangiogenesis correlates with metastasis in invasive prostate carcinoma 143 : 401 ~ 409
/ 1995 / Allelic loss of sequences from the long arm of chromosome10 and replicaton errors in endometrial cancers 55 : 1922 ~ 1926
/ 1995 / Loss of chromosomal region 10q23-25 in prostate cancer 55 : 4800 ~ 4803
/ 1996 / How tumors become angiogenic. 69 : 135 ~ 174
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A Clinical Analysis of PTEN Expressions in Breast Cancers
Cancer Research and Treatment
2003 .01
-
Loss of PTEN Expression in Breast Cancers
Journal of Pathology and Translational Medicine
2005 .01
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Loss of PTEN Expression in Primary Lung Cancer
Journal of Pathology and Translational Medicine
2002 .01
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Prognostic Role of PTEN Gene Expression and Length of Survival of Breast Cancer Patients in the North East of Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Prognostic Role of PTEN Gene Expression in Breast Cancer Patients from North-East Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Analysis of PTEN, VEGF, HER2 and P53 Status in Determining Colorectal Cancer Benefit from Bevacizumab Therapy
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-small Cell Lung Cancer
Journal of Pathology and Translational Medicine
2011 .01
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침윤성 유방암에서 PTEN 단백 발현과 다른 예후인자들과의 관계
Annals of Surgical Treatment and Research
2004 .04
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Sodium Iodide Symporter and Phosphatase and Tensin Homolog Deleted on Chromosome Ten Expression in Cholangiocarcinoma Analysis with Clinicopathological Parameters
Gut and Liver
2012 .01
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유방암에서 Insulin-like Growth Factor Binding Protein (IGFBP)-3 및 PTEN 발현의 감소와 임상병리학적 소견과의 관련성
Annals of Surgical Treatment and Research
2010 .08
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폐암 조직에서의 PTEN 발현 정도와 Gefitinib의 반응율과의 관계
Tuberculosis and Respiratory Diseases
2005 .01
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Loss of Expression of PTEN is Associated with Worse Prognosis in Patients with Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Over-expression of PTEN Involved in Troglitazone-induced Apoptosis in Human Osteosarcoma Cells
대한골관절종양학회지
2011 .01
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Roles of PTEN (Phosphatase and Tensin Homolog) in Gastric Cancer Development and Progression
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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Prediction and Analysis of Breast Cancer Related Deleterious Non-Synonymous Single Nucleotide Polymorphisms in the PTEN Gene
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors
Journal of Pathology and Translational Medicine
2014 .01
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Predictive and Prognostic Significance of p27, Akt, PTEN and PI3K Expression in HER2-Positive Metastatic Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Upregulation of Estrogen Receptor by Tumor Suppressor Protein PTEN in Breast Cancer Cell Line MCF-7 Cells
대한외과학회 학술대회 초록집
2005 .05
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PTEN Mutation Identified in Patient Diagnosed with Simultaneous Multiple Cancers
Cancer Research and Treatment
2019 .01
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