지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 302 - 307 (6page)
이용수
초록· 키워드
오류제보하기
Novel amylase inhibitors were synthesized via transglycosylation by Thermotoga maritima glucosidase (TMG). TMG hydrolyzes acarbose, acarviosine-glucose, and maltooligosaccharide by releasing <sup>14</sup>C-labeled glucose from the reducing end of each molecule. When TMG was incubated with acarviosine-glucose (the donor) and glucose (the acceptor), two major transfer products, compounds 1 and 2, were formed via transglycosylation. The structures of the transfer products were determined using thin-layer chromatography (TLC), high-performance ion chromatography (HPIC), and <sup>13</sup>C nuclear magnetic resonance (NMR) spectroscopy. The results indicate that acarviosine was transferred to glucose at either C-6, to give a α-(1→6) glycosidic linkage, or at C-3, to produce an α-(1→3) glycosidic linkage. The transfer products showed a mixed-type inhibition against porcine pancreatic α-amylase; therefore, they may be useful not only as inhibitors but also as acarbose transition-state analogs to study the mechanism of amylase inhibition.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Schmidt DD / 1977 / α-Glucosidase inhibitors. New complex oligosaccharides of microbial origin / Naturwissenschaften 64 : 535 ~ 536
2. [학술지(정기간행물)] - Aleshin AE / 1994 / Refined structure for the complex of acarbose with glucoamylase from Aspergillus awamori var. X100 to 2.4-Å resolution / J. Biol. Chem 269 : 15631 ~ 15639
3. [학술지(정기간행물)] - Brzozowski AM / 1997 / Structure of the Aspergillus oryzae α- amylase complexed with the inhibitor acarbose at 2.0Å resolution / Biochemistry 36 : 10837 ~ 10845
4. [학술지(정기간행물)] - Strokopytov B / 1995 / X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose. Implications for the catalytic mechanism of glycosidases / Biochemistry 34 : 2234 ~ 2240
5. [학술지(정기간행물)] - Schöffling K / 1980 / Treatment of diabetes mellitus with the glycoside hydrolase inhibitor acarbose (BAY-g- 5421) / Front. Horm. Res 7 : 248 ~ 257
2. [학술지(정기간행물)] - Aleshin AE / 1994 / Refined structure for the complex of acarbose with glucoamylase from Aspergillus awamori var. X100 to 2.4-Å resolution / J. Biol. Chem 269 : 15631 ~ 15639
3. [학술지(정기간행물)] - Brzozowski AM / 1997 / Structure of the Aspergillus oryzae α- amylase complexed with the inhibitor acarbose at 2.0Å resolution / Biochemistry 36 : 10837 ~ 10845
4. [학술지(정기간행물)] - Strokopytov B / 1995 / X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose. Implications for the catalytic mechanism of glycosidases / Biochemistry 34 : 2234 ~ 2240
5. [학술지(정기간행물)] - Schöffling K / 1980 / Treatment of diabetes mellitus with the glycoside hydrolase inhibitor acarbose (BAY-g- 5421) / Front. Horm. Res 7 : 248 ~ 257
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cloning And Characterization Of Thermostable α-amylase From Thermotoga maritima
한국토양비료학회 학술발표회 초록집
2000 .05
-
Screening of Oriental Drugs for a-Amylase Inhibitor
한국식품과학회지
1988 .10
-
Partial Purification and Some Properties of Amylases from Germinating Corn(Zea mays L.)
한국식품영양과학회지
1990 .12
-
細菌 Amylase 生産에 關한 硏究 (第1報) : 菌의 分離, 同定, Amylase 生産條件 및 生成酵素의 酵素的性質에 對하여
한국식품과학회지
1969 .12
-
Amylase의 종류와 그 산업적 이용
식품공업
1986 .01
-
100종 브라질 식물 추출물로부터 반추동물 산독증 예방치료를 위한 α-amylase 및 α-glucosidase 저해제의 선별
Food Science and Preservation
2010 .04
-
Herpetosiphon geysericola 균주의 Amylase 생성
한국식품영양과학회지
1985 .05
-
무의 α-Amylase 활성 및 가공 안정성
한국식품영양과학회지
2009 .06
-
세균(細菌)에 의(依)한 Amylase생산(生産)에 관한 연구(硏究)
Applied Biological Chemistry
1970 .01
-
한국산 검정콩 α-Amylase 저해물질의 분리 및 정제
한국식품과학회지
1995 .10
-
Studies on Enzyme of the Thermophilic Mold-Part. 3. Thermophilic mold amylase-
Applied Biological Chemistry
1970 .01
-
보리와 밀 맥아 Amylases의 반응속도론적 연구
한국식품위생안전성학회지
1991 .01
-
[P8-171] 곡류 추출물의 α-amylase와 α-glucosidase 저해 활성
한국식품영양과학회 학술대회발표집
2009 .11
-
Studies on Acid-stable Alpha-amylase
Applied Biological Chemistry
1978 .01
-
Investigation of structural factors for alpha-amylase inhibition of fucoidan
한국수산과학회 양식분과 학술대회
2018 .05
-
Molecular Cloning and Characterization of a Gene Encoding Thermostable Pectinase from Thermotoga maritima
Journal of applied biological chemistry
2014 .01
-
[P8-01] The Structural Study of Sulfonamide Chalcones for the Inhibition of Human Pancreatic α-Amylase
한국식품영양과학회 학술대회발표집
2007 .10
-
강원도 자생 산채 추출물의 α-Amylase, α-Glucosidase, Lipase 효소 저해활성 탐색
한국식품영양과학회지
2011 .02
-
옥수수의 발아과정중(發芽過程中) AMYLASE활성(活性)
Applied Biological Chemistry
1984 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-573-001015395