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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.19 No.4
- 발행연도
- 2014.12
- 수록면
- 261 - 267 (7page)
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As a part of ongoing research to elucidate and characterize antioxidant and anti-inflammatory nutraceuticals, solvent-partitioned fractions from Spergularia marina were tested for their ability to scavenge radicals and suppress inflammation. The results of the 2’,7’-dichlorofluorescein diacetate assay indicate that solvent-partitioned fractions from S. marina scavenged intracellular radicals in H₂O₂-stimulated mouse macrophages. The tested fractions decreased the generation of nitric oxide (NO) and the expression of inflammation mediators, namely, inducible nitric oxide synthase (iNOS) and interleukin (IL)-6, by lipopolysaccharide (LPS)-induced mouse macrophages, indicating that S. marina decreases inflammation. Among all tested fractions [i.e., H₂O, n-buthanol (n-BuOH), 85% aqueous methanol (aq. MeOH), and n-hexane], the 85% aq. MeOH fraction showed the strongest antioxidant and anti-inflammatory response. The 85% aq. MeOH fraction scavenged 80% of the free radicals produced by H₂O₂-induced control cells. In addition, NO production was 98% lower in 85% aq. MeOH fraction-treated cells compared to LPS-induced control cells. The mRNA expression of iNOS and IL-6 was also suppressed in 85% aq. MeOH fraction-treated cells. The results of the current study suggest that the phenolic compound components of S. marina are responsible for its antioxidant and anti-inflammatory effects.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Berlett BS / 1997 / Protein oxidation in aging, disease, and oxidative stress / J Biol Chem 272 : 20313 ~ 20316
2. [학술지(정기간행물)] - Mayne ST / 2003 / Antioxidant nutrients and chronic disease:use of biomarkers of exposure and oxidative stress status in epidemiologic research / J Nutr 133 : 933S ~ 940S
3. [학술지(정기간행물)] - Holvoet P / 2008 / Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease / Verh K Acad Geneeskd Belg 70 : 193 ~ 219
4. [학술지(정기간행물)] - Elmarakby AA / 2012 / Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy / Cardiovasc Ther 30 : 49 ~ 59
5. [학술지(정기간행물)] - Khansari N / 2009 / Chronic inflammation and oxidative stress as a major cause of agerelated diseases and cancer / Recent Pat Inflamm Allergy Drug Discov 3 : 73 ~ 80
2. [학술지(정기간행물)] - Mayne ST / 2003 / Antioxidant nutrients and chronic disease:use of biomarkers of exposure and oxidative stress status in epidemiologic research / J Nutr 133 : 933S ~ 940S
3. [학술지(정기간행물)] - Holvoet P / 2008 / Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease / Verh K Acad Geneeskd Belg 70 : 193 ~ 219
4. [학술지(정기간행물)] - Elmarakby AA / 2012 / Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy / Cardiovasc Ther 30 : 49 ~ 59
5. [학술지(정기간행물)] - Khansari N / 2009 / Chronic inflammation and oxidative stress as a major cause of agerelated diseases and cancer / Recent Pat Inflamm Allergy Drug Discov 3 : 73 ~ 80
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UCI(KEPA) : I410-ECN-0101-2016-594-001045045