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논문 기본 정보

자료유형
학술저널
저자정보
Jae-Young Cha Jin-Sun Heo (동아대학교) Young-Su Cho (동아대학교)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 6
발행연도
2008.12
수록면
1,207 - 1,213 (7page)

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초록· 키워드

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The possible protective effects of highly zinc-containing yeast Saccharomyces cerevisiae, FF-10 strain, isolated from tropical fruit rambutan on acute alcoholic liver injury in rats were evaluated. Zinc concentration in this strain was 30.6 ㎎%. The activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase (γ-GTP) were highly increased when alcohol was treated, relative to the normal rats. Also, a highly significant increase in the blood alcohol and acetaldehyde levels by alcohol treatment was observed. Administration of FF-10 strain markedly prevented alcohol-induced elevation of the activities of serum ALT, AST, and γ-GTP, and the levels of blood alcohol and acetaldehyde, and these reduced levels reached to that of normal rats. As compared with alcohol treated control rats, the FF-10 strain supplementation showed highly decreased the triglyceride concentration in serum. Alcohol treatment induced the marked accumulation of small lipid droplets, hepatocytes necrosis, and inflammation, but FF-10 strain administration attenuated to alcohol-induced accumulation of small lipid droplets and hepatocyte necrosis in the liver. Therefore, the current finding suggests that zinc-enriched yeast FF-10 strain isolated from tropical fruit rambutan may have protective effect against alcoholinduced hepatotoxicity.

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Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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