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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.3
- 수록면
- 11 - 21 (11page)
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In this study, we investigated the role of toll-like receptor (TLR) and mitogen-activated protein kinase (MAPK) pathways involved in the tumor necrosis factor (TNF)-α and interleukin (IL)-6 expression after stimulation with purified protein derivatives (PPD) or native 38-kDa protein antigen (Ag) of Mycobacterium tuberculosis H37Rv in human primary monocytes. Both PPD and 38-kDa Ag significantly induced TNF-α and IL-6 in human primary monocytes. MAPK [extracellular signal-regulated kinase (ERK) 1/2 and p38] are rapidly phosphorylated in human monocytes stimulated with the PPD or 38-kDa Ag. Both p38 and ERK 1/2 activation are essential for PPD- or 38-kDa-induced TNF-α and IL-6 production. The inhibition of TLR2 and TLR4 by specific antibodies significantly abrogated the 38-kDa-induced secretion of TNF-α and IL-6, whereas blockade of TLR2, but not TLR4, was responsible for the PPD-induced TNF-α and IL-6 production in human monocytes. Collectively, these data suggest that the PPD and 38-kDa Ag differentially interact with TLR2 and TLR4, which in turn mediate an essential role for the early inflammatory immune responses during human tuberculosis.
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참고문헌
참고문헌 (37)
참고문헌 신청
백태현 , 2004 , 결핵균의 TSP 균체항원으로부터 특이항원의 분리 및 특성 분석 34 : 273 ~ 282
이지숙 , 2006 , 결핵균 배양여과액으로부터 Ag85 Complex, 38-kDa 및 MTB12 항원의 분리정제 , Journal of Bacteriology and Virology 36 (4) : 211 ~ 220
Andersen P , 1994 , Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 62 : 2536 ~ 2544
Andersen P , 1994 , The T cell response to secreted antigens of Mycobacterium tuberculosis. Immunobiology 191 : 537 ~ 547
Blumenthal A , 2002 , Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways 70 : 4961 ~ 4967
이지숙 , 2006 , 결핵균 배양여과액으로부터 Ag85 Complex, 38-kDa 및 MTB12 항원의 분리정제 , Journal of Bacteriology and Virology 36 (4) : 211 ~ 220
Andersen P , 1994 , Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 62 : 2536 ~ 2544
Andersen P , 1994 , The T cell response to secreted antigens of Mycobacterium tuberculosis. Immunobiology 191 : 537 ~ 547
Blumenthal A , 2002 , Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways 70 : 4961 ~ 4967
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UCI(KEPA) : I410-ECN-0101-2010-475-002456995