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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 241 - 248 (8page)
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In this study, we examined the expression of Toll-like receptor3 (TLR3) by human retinal pigment epithelial cells (RPE) and determined whether exposure to the TLR3 agonist polyinosinic-polycytidylic acid (poly I:C) would induced the expression of cytokines in these cells. RT-PCR revealed that TLR3 was constitutively expressed in human RPE, and its expression was increased by treatment with poly I:C. After treatment with poly I:C, we determined the expression levels of pro-inflammatory cytokines in human RPE using RT-PCR and ELISA. We demonstrated that poly I:C treatment increased the production of TNF-α, IL-6, and IL-8 in human RPE. Upon exposure to poly I:C, human RPE initiated antiviral response resulting in the induction of IFN-β mRNA expression and 2',5'-oligoadenylate synthetase mRNA expression. These results suggest that human RPE may participate in ocular defense mechanism against viral infection through TLR3.
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참고문헌
참고문헌 (30)
참고문헌 신청
Akira S , 2003 , Mammalian Toll-like receptors 15 : 5 ~ 11
Chang JH , 2006 , Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. 90 : 103 ~ 108
Choi SJ , 2007 , The Expression Pattern of Toll-like receptor (TLR) and Cytokine production to TLR Agonists in Human Retinal Pigment Epithlial Cells 37 : 119 ~ 128
Detrick B , 1996 , Cytomegalovirus replication in human retinal pigment epithelial cells. Altered expression of viral early proteins 37 : 814 ~ 825
Elner SG , 2005 , TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression 103 : 126 ~ 137
Chang JH , 2006 , Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. 90 : 103 ~ 108
Choi SJ , 2007 , The Expression Pattern of Toll-like receptor (TLR) and Cytokine production to TLR Agonists in Human Retinal Pigment Epithlial Cells 37 : 119 ~ 128
Detrick B , 1996 , Cytomegalovirus replication in human retinal pigment epithelial cells. Altered expression of viral early proteins 37 : 814 ~ 825
Elner SG , 2005 , TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression 103 : 126 ~ 137
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사람 망막색소상피에서 Toll-like Receptor (TLR) 발현양상과 TLR Agonist들에 의한 사이토카인 발현유도
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Immunological Features of Macrophages Induced by Various Morphological Structures of Candida albicans
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Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes
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Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes
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UCI(KEPA) : I410-ECN-0101-2010-475-002451763