지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
HSP90에 노출된 혈관평활근세포에서 IL-6 transcript가 증가하고, IL-6 단백질의 분비가 증가하며, 또한 IL-6 유전자의 promote가 활성화되었다. HSP90에 의한 IL-6 유전자의 promoter 활성화는 dominant negative 형태의 TLR-4와 MyD88에 의하여 크게 감소되었지만, dominant negative 형태의 TLR-3와 TRIF의 영향을 받지 않았다. 그리고 TLR-4의 이합체화(dimerization)를 저해하는 curcumin은 HSP90에 의한 IL-6의 분비 및 IL-6 유전자 promoter 활성화를 억제하였다. 그리고 IL-6 유전자의 promoter의 NF-κB- 또는 C/EBP-binding sequence에 변이는 HSP90에 의한 IL-6 유전자의 promoter 활성화 억제하였다. 이러한 결과는 혈관평활근세포에서 HSP90에 의한 IL-6 유전자 활성화에 TLR-4와 NF-κB가 관여함을 의미한다.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgement
References
초록
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Akira, S. / 2004 / Toll-like receptor signalling / Nat. Rev. Immunol 4 : 499 ~ 511
2. [학술지(정기간행물)] - Basu, S. / 2000 / Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway / Int. Immunol 12 : 1539 ~ 1546
3. [학술지(정기간행물)] - Edfeldt, K. / 2002 / Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation / Circulation 105 : 1158 ~ 1161
4. [학술지(정기간행물)] - Eickelberg, O. / 1999 / Calcium channel blockers activate the interleukin-6 gene via the transcription factors NF-IL6 and NF-kappaB in primary human vascular smooth muscle cells / Circulation 99 : 2276 ~ 2282
5. [학술지(정기간행물)] - Hollestelle, S. C. / 2004 / Toll-like receptor 4 is involved in outward arterial remodeling / Circulation 109 : 393 ~ 398
2. [학술지(정기간행물)] - Basu, S. / 2000 / Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway / Int. Immunol 12 : 1539 ~ 1546
3. [학술지(정기간행물)] - Edfeldt, K. / 2002 / Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation / Circulation 105 : 1158 ~ 1161
4. [학술지(정기간행물)] - Eickelberg, O. / 1999 / Calcium channel blockers activate the interleukin-6 gene via the transcription factors NF-IL6 and NF-kappaB in primary human vascular smooth muscle cells / Circulation 99 : 2276 ~ 2282
5. [학술지(정기간행물)] - Hollestelle, S. C. / 2004 / Toll-like receptor 4 is involved in outward arterial remodeling / Circulation 109 : 393 ~ 398
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