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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 421 - 438 (18page)
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초록· 키워드
오류제보하기
Toll-like receptors (TLRs) are the archetypal pattern recognition
receptors in sensing exogenous pathogens.
Activation of TLRs is a first line of defense of the immune
system, leading to the activation and recruitment of neutrophils
and macrophages to sites of infection and enhances
antimicrobial activity. The TLR signaling
through different intracellular molecules, such as MAP
kinases and IκB kinases which are conserved signaling
elements for many receptors, leads to a distinct set of
proinflammatory gene expressions. However, how
these pathways differentially and precisely control the
transcription of identical genes remains largely
unknown. Our review focuses on the details of up-todate
signaling molecules including negative regulators
and their role in controlling innate immune response.
We also stress the importance of developing systemic
approaches for the global understanding of TLR signaling
so that appropriate drug therapeutic targets can be
identified for regulating inflammatory diseases.
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