지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 199 - 205 (7page)
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초록· 키워드
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This study was designed to investigate direct effects of [D-Pen², D-Pen?]-enkephalin, a δ-opioid receptor agonist on the neuronal activity of medial vestibular nuclear (MVN) neurons by whole-cell configuration patch clamp experiments. The spike frequency of MVN neuron was increased to 9.50±0.55 (P＜0.05) and 10.56±0.66 (P＜0.05) by 5 and 10 μM [D-Pen², D-Pen?]-enkephalin from the control level of 8.05±0.55 spikes/sec, respectively (n=18). The resting membrane potential of the neurons was increased to -37.86±0.92 and -36.97±0.97 (P＜0.05) from -38.74±1.13 ㎷ by 5 and 10 μM [D-Pen², D-Pen?]-enkephalin, respectively. The amplitude of afterhyperpolarization was decreased to 23.78±0.65 and 21.67±0.89 (P＜0.05) from 23.73±0.53 ㎷ by 5 and 10 μM [D-Pen², D-Pen?]-enkephalin, respectively. The spike width was changed to 2.22±0.08 and 2.24±0.07 from 2.20±0.08 ㎷ by 5 and 10 μM [D-Pen², D-Pen?]-enkephalin, respectively. After pretreatment of naltrindole, a highly selective δ-opioid receptor antagonist, [D-Pen², D-Pen?]-enkephalin did not change firing rate, resting membrane potential, afterhyperpolarization amplitude, and spike width of MVN neurons. The above experimental results suggest that [D-Pen², D-Pen?]-enkephalin increases the neuronal activity of MVN neurons via inhibition of calcium-dependent potassium currents underlying the afterhyperpolarization.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
Acknowledgements
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-510-018855923