지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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This study was designed to investigate the effects of sphingosine-1-phosphate on the neuronal activity of rat medial vestibular nuclear neurons. Sprague-Dawley rats aged 14 to 16 days were decapitated under ether anesthesia. After treatment with pronase and thermolysin, the dissociated medial vestibular nuclear neurons were transferred into a chamber on an inverted microscope. Spontaneous action potentials and potassium currents were recorded by standard patch-clamp techniques under current and voltage-clamp modes respectively. 15 medial vestibular nuclear neurons revealed excitatory responses to 1 and 5 μM of sphingosine-1-phosphate. The spike frequency and resting membrane potential of these cells were increased by sphingosine-1-phosphate. The amplitude of afterhyperpolarization was decreased by sphingosine-1-phosphate. Whole potassium currents of medial vestibular nuclear neurons were decreased by sphingosine-1-phosphate (n=12). Sphingosine-1-phosphate did not affect the charybdotoxin-treated potassium currents. These experimental results suggest that sphingosine-1-phosphate increases the neuronal activity of the medial vestibular nuclear neurons by altering the resting membrane potential and afterhyperpolarization.
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재료 및 방법
결과
고찰
감사의 글
REFERENCES
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Aoki M / 1996 / Evidence for the involvement of NMDA receptors in vestibular compensation / J Vet Res 6 : 315 ~ 317
2. [학술지(정기간행물)] - Balaban CD / 1994 / Vestibular nucleus projections to nucleus tractus golitarius and the dorsal motor nucleus of the vagus nerve: potential substrates for vestibulo-autonomic interactions / Exp Br Res 96 : 200 ~ 212
3. [학술지(정기간행물)] - Benamer N / 2009 / Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts / J Mol Cell Cardiol 46 : 508 ~ 517
4. [학술지(정기간행물)] - Birbes H / 2001 / Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis / FASEB J. 15 : 2669 ~ 2679
5. [학술지(정기간행물)] - Bock I / 2003 / Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms / Biochem Biophys Res Commun 305 : 890 ~ 897
2. [학술지(정기간행물)] - Balaban CD / 1994 / Vestibular nucleus projections to nucleus tractus golitarius and the dorsal motor nucleus of the vagus nerve: potential substrates for vestibulo-autonomic interactions / Exp Br Res 96 : 200 ~ 212
3. [학술지(정기간행물)] - Benamer N / 2009 / Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts / J Mol Cell Cardiol 46 : 508 ~ 517
4. [학술지(정기간행물)] - Birbes H / 2001 / Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis / FASEB J. 15 : 2669 ~ 2679
5. [학술지(정기간행물)] - Bock I / 2003 / Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms / Biochem Biophys Res Commun 305 : 890 ~ 897
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UCI(KEPA) : I410-ECN-0101-2010-510-002142850