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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Microtubule-interfering agents (MIAs), including paclitaxel, have been attributed in part to interference with microtubule assembly, impairment of mitosis, and changes in cytoskeleton. But the signaling mechanisms that link microtubule disarray to destructive or protective cellular responses are poorly understood. This study investigated the effect of paclitaxel on differentiation such as type II collagen expression and sulfated proteoglycan accumulation in rabbit articular chondrocytes. Paclitaxel caused differentiated chondrocyte phenotype as demonstrated by increment of type II collagen expression and proteoglycan synthesis Paclitaxel treatment stimulated activation of ERK-1/2 and p38 kinase. Inhibition of ERK-1/2 with PD98059 enhanced paclitaxel-induced differentiation, whereas inhibition of p38 kinase with SB203580 suppressed paclitaxel-induced differentiation. Our findings suggest that ERK-1/2 and p38 kinase oppositely regulate paclitaxel-induced differentiation in chondrocytes.
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Paclitaxel Stimulates Cyclooxygenase-2 Expression via MAP Kinase Pathway in Rabbit Articular Chondrocytes
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Enhanced Paclitaxel Bioavailability after Oral Administration of Paclitaxel Coadministered with Quercetin in Rats.
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횐쥐의 대장점막에 Paclitaxel(Taxol)과 방사선조사의 효과
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흰쥐의 위점막에 Paclitaxel (Taxol)과 방사선조사의 효과
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Mass Production of Paclitaxel by Plant Cell Culture
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Clinical Comparison between Paclitaxel Liposome (Lipusu) and Paclitaxel for Treatment of Patients with Metastatic Gastric Cancer
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Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling
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Proteome Analysis of Differential Protein Expression in Cervical Cancer Cells after Paclitaxel Treatment
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상피성 난소암 세포에서 MyD88 발현과 paclitaxel의 항세포고사 신호
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프라본과 파크리탁셀과의 약물상호작용
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Paclitaxel-Platinum 제제를 기본으로 한 항암화학요법 후 재발한 난소암 환자에서 Paclitaxel-Carboplatin 복합항암화학요법의 효용성
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Inhibition of NF-κB/Rel by Paclitaxel in Mouse Macrophages
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Pretreatment of Macrophages with Paclitaxel Inhibits iNOS Expression
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Pharmacokinetics of Paclitaxel in Rabbits with Carbon Tetrachloride-Induced Hepatic Failure
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2002 .01
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Enhanced Bioavailability of Paclitaxel by Bamboo Concentrate Administration
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
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Identification of P-Glycoprotein and Transport Mechanism of Paclitaxel in Syncytiotrophoblast Cells
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