지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 135 - 141 (7page)
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초록· 키워드
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Background:Although paclitaxel is a widely used chemotherapeutic agent for the treatment of solid cancers, side effects such as neuropathic pain lead to poor compliance and discontinuation of the therapy. Ethyl pyruvate (EP) is known to have analgesic effects in several pain models and may inhibit apoptosis. The present study was designed to investigate the analgesic effects of EP on mechanical allodynia and apoptosis in dorsal root ganglion (DRG) cells after paclitaxel administration.
Methods:Rats were randomly divided into 3 groups: 1) a control group, which received only vehicle; 2) a paclitaxel group, which received paclitaxel; and 3) an EP group, which received EP after paclitaxel administration. Mechanical allodynia was tested before and at 7 and 14 days after final paclitaxel administration. Fourteen days after paclitaxel treatment, DRG apoptosis was determined by activated caspase-3 immunoreactivity (IR).
Results:Post-treatment with EP did not significantly affect paclitaxel-induced allodynia, although it tended to slightly reduce sensitivities to mechanical stimuli after paclitaxel administration. After paclitaxel administration, an increase in caspase-3 IR in DRG cells was observed, which was co-localized with NF200-positive myelinated neurons. Post-treatment with EP decreased the paclitaxel-induced caspase-3 IR. Paclitaxel administration or post-treatment with EP did not alter the glial fibrillary acidic protein IRs in DRG cells.
Conclusions:Inhibition of apoptosis in DRG neurons by EP may not be critical in paclitaxel-induced mechanical allodynia.
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참고문헌 (24)
참고문헌 신청
Boyette-Davis J / 2011 / Intraepidermal nerve fiber loss corresponds to the development of taxol-induced hyperalgesia and can be prevented by treatment with minocycline / Pai
Cavaletti G / 1995 / Peripheral neurotoxicity of taxol in patients previously treated with cisplatin / Cancer 75 : 1141 ~ 1150
Choi JS / 2010 / Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model / BIOCHEMICAL AND BIOPH
Dae Kee Choi / 2012 / Effects of Ethyl Pyruvate on Allodynia, TNF-α Expression, and Apoptosis in the Dorsal Root Ganglion after Spinal Nerve Ligation Injury / The Korean Jo
Forsyth PA / 1997 / Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing / J Neurooncol 35 : 47 ~ 53
Cavaletti G / 1995 / Peripheral neurotoxicity of taxol in patients previously treated with cisplatin / Cancer 75 : 1141 ~ 1150
Choi JS / 2010 / Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model / BIOCHEMICAL AND BIOPH
Dae Kee Choi / 2012 / Effects of Ethyl Pyruvate on Allodynia, TNF-α Expression, and Apoptosis in the Dorsal Root Ganglion after Spinal Nerve Ligation Injury / The Korean Jo
Forsyth PA / 1997 / Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing / J Neurooncol 35 : 47 ~ 53
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