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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.3
- 수록면
- 19 - 24 (6page)
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초록· 키워드
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We demonstrate that paclitaxel, an antitumor agent derived from yew tree, inhibits LPS- and IFN-γ-induced NF-κB/Rel activation in RAW 264.7 cells. Previously, paclitaxel (＞ 10 μM) has been known to induce iNOS gene expression in macrophages. However, in the previous report we described that the pretreatment of macrophages with low concentration of paclitaxel (0.1 μM) for 8 h inhibited LPSinduced iNOS gene expression. Pretreatment of RAW 264.7 cells with paclitaxel significantly inhibited NF-κB/Rel transcriptional activation. Electrophoretic mobility shift assay further confirmed that pretreatment of macrophages with paclitaxel inhibited NF-κB/Rel DNA binding. Taxotere, a semisynthetic analog of paclitaxel, also inhibited LPS- and IFN-γ-induced iNOS gene expression. Collectively, these series of experiments indicate that paclitaxel inhibits iNOS gene expression by blocking NF-κB/Rel activation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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Pretreatment of Macrophages with Paclitaxel Inhibits iNOS Expression
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Stalility of Paclitaxel with Cephalosporines in 0.8 Sodium Chloride Injection and 5 Dextrose Injection During Simulated Y-Site Administration
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Enhanced Paclitaxel Bioavailability after Oral Administration of Paclitaxel Coadministered with Quercetin in Rats.
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Effect of Ethyl Pyruvate on Paclitaxel-Induced Neuropathic Pain in Rats
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Response to Paclitaxel in Node-positive Triple Negative Breast Cancer
Annals of Surgical Treatment and Research
2010 .09
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Mass Production of Paclitaxel by Plant Cell Culture
대한약학회 학술대회
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흰쥐의 위점막에 Paclitaxel (Taxol)과 방사선조사의 효과
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1999 .01
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흰쥐의 소장점막에 Paclitaxel(Taxol)과 방사선조사의 효과
Radiation oncology journal : ROJ
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Paclitaxel Stimulates Cyclooxygenase-2 Expression via MAP Kinase Pathway in Rabbit Articular Chondrocytes
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2009 .06
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횐쥐의 대장점막에 Paclitaxel(Taxol)과 방사선조사의 효과
Radiation oncology journal : ROJ
1999 .01
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Paclitaxel Suppress Dedifferentiation via Mitogen-activated Protein Kinase Pathway in Rabbit Articular Chondrocyte
대한의생명과학회지
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Synergistic Effect of COX-2 Inhibitor on Paclitaxel-Induced Apoptosis in the Human Ovarian Cancer Cell Line OVCAR-3
Cancer Research and Treatment
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Clinical Comparison between Paclitaxel Liposome (Lipusu) and Paclitaxel for Treatment of Patients with Metastatic Gastric Cancer
Asian Pacific journal of cancer prevention : APJCP
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상피성 난소암 세포에서 MyD88 발현과 paclitaxel의 항세포고사 신호
Obstetrics & Gynecology Science
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Proteome Analysis of Differential Protein Expression in Cervical Cancer Cells after Paclitaxel Treatment
Cancer Research and Treatment
2004 .01
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프라본과 파크리탁셀과의 약물상호작용
약학회지
2003 .01
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Paclitaxel-Platinum 제제를 기본으로 한 항암화학요법 후 재발한 난소암 환자에서 Paclitaxel-Carboplatin 복합항암화학요법의 효용성
Obstetrics & Gynecology Science
2004 .01
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함초에서 분리한 다당체에 의한 큰포식세포 활성화
해부·생물인류학
2006 .06
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UCI(KEPA) : I410-ECN-0101-2009-513-016602069