지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 221 - 225 (5page)
이용수
초록· 키워드
오류제보하기
Recent studies have shown that stem cells improve neurological deficits when transplanted into animal models of neurological disorders. Neurotrophins such as brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), neurotrophin-3 (NT-3), and nerve growth factor (NGF) are important modulators of neuronal function and survival. Their expression in the CNS after various insults is thus of major therapeutic consequence. The goal of our current study was to investigate whether adipose tissue derived-stem cell (ADSC) transplantation affects the expression of neurotrophins in neurodegenerative lysosomal disease, Niemann-Pick Type C (NP-C) mice. Our findings showed high BDNF expression but not CNTF, NT-3 and NGF in the ADSC transplanted NP-C mice compared to sham transplanted control mice. These results strongly suggest that BDNF expression by ADSC transplantation prevents Purkinje neuron loss in the cerebellum of NP-C mice. In summary, the results in the present study demonstrated that the transplantation of ADSCs activates neurotrophin and thus that it might be useful as a therapeutic tool for treatment of neurodegenerative brain disease.
목차
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Aharoni, R / 2005 / The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice / Proc. Natl. Acad. Sci. USA 102 : 19045 ~ 19050
2. [학술지(정기간행물)] - Bae, J.S / 2005a / Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells / Neurosci. Lett 381 : 234 ~ 236
3. [학술지(정기간행물)] - Bae, J.S / 2005b / Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice / Hum. Gene. Ther 16 : 1006 ~ 1011
4. [학술지(정기간행물)] - Bae, J.S / 2007 / Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration / Stem Cells 25 : 1307 ~ 1316
5. [학술지(정기간행물)] - Endo, S / 1999 / Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells / Proc. Natl. Acad. Sci. USA 96 : 2467 ~ 2471
2. [학술지(정기간행물)] - Bae, J.S / 2005a / Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells / Neurosci. Lett 381 : 234 ~ 236
3. [학술지(정기간행물)] - Bae, J.S / 2005b / Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice / Hum. Gene. Ther 16 : 1006 ~ 1011
4. [학술지(정기간행물)] - Bae, J.S / 2007 / Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration / Stem Cells 25 : 1307 ~ 1316
5. [학술지(정기간행물)] - Endo, S / 1999 / Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells / Proc. Natl. Acad. Sci. USA 96 : 2467 ~ 2471
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UCI(KEPA) : I410-ECN-0101-2009-510-014844057