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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 71 - 76 (6page)
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초록· 키워드
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The neurotrophin plays an important role in the
development, differentiation and survival of the nervous
system in vertebrates. It exerts its cellular effects through
two different receptors, the Trk receptor tyrosine kinase
neurotrophin receptor and the p75 neurotrophin receptor,
member of the tumor necrosis factor receptor superfamily.
Trk and p75 neurotrophin receptors utilize specific target
proteins to transmit signals into the cell. An ankyrin-rich
membrane spanning protein (ARMS) was identified as
new p75 interacting protein and serves as a novel
downstream target of p75 neurotrophin receptor. We
sought to delineate the interaction between p75 and ARMS
by deletion constructs of p75 and green fluorescent protein
(GFP)-tagged ARMS. We examined the interaction
between these two proteins after overexpressing them in
HEK-293 cells. Using both Western blot analysis and
immunocytochemistry followed by confocal laser scanning
microscopy, we found out that the intracellular domain of
the p75 neurotrophin receptor was important for the
interaction with ARMS. The results from this study suggest
that ARMS may play an important role for mediating the
signals from p75 neurotrophin receptor into the cell.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Arevalo, J. C. / 2004 / A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein / EMBO Journal 23 : 2358 ~ 2368
Bibel, M. / 1999 / Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR / EMBO Journal 8 : 616 ~ 622
Cabrera-Poch, N. / 2004 / Lipid raft disruption triggers protein kinase C and Src-dependent protein kinase D activation and Kidins220 phosphorylation in neuronal cells / Jour
Carter, B. D. / 1996 / Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75 / Science 272 : 542 ~ 545
Chang, M.-S. / 2004 / Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein / Journal of Neuroscience Research 78 : 186 ~ 192
Bibel, M. / 1999 / Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR / EMBO Journal 8 : 616 ~ 622
Cabrera-Poch, N. / 2004 / Lipid raft disruption triggers protein kinase C and Src-dependent protein kinase D activation and Kidins220 phosphorylation in neuronal cells / Jour
Carter, B. D. / 1996 / Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75 / Science 272 : 542 ~ 545
Chang, M.-S. / 2004 / Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein / Journal of Neuroscience Research 78 : 186 ~ 192
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