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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제3권 제2호
- 발행연도
- 2010.1
- 수록면
- 84 - 90 (7page)
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초록· 키워드
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Objectives. Treating olfactory dysfunction is a challenge for physicians. One of the therapeutic options could be transplantation of stem cells. In this study, neural stem cells were transplanted into anosmic mice.
Methods. Neural stem cells were generated from the olfactory bulb of green fluorescent protein (GFP)-transgenic C57BL6 mice. Anosmia were induced by injection of intraperitoneal 3-methylindole. The neural stem cells were transplanted transnasally on the next day. The olfactory function was evaluated by a food-finding test once a week.
The olfactory neuroepithelium was harvested for histologic examination and protein analysis at 4 weeks.
Results. Twenty-five percent (6/24) of the control mice that were not transplanted with neural stem cells survived at 4weeks while 67% (8/12) of the transplanted mice survived (P=0.029). The food finding test showed that the transplanted mice resumed finding food at 3 weeks while the control mice resumed finding food at 4 weeks. GFP-positive cells were observed in the olfactory neuroepithelium of the transplanted mice. Western blotting revealed that the olfactory marker protein expression was significantly lower in the control mice than that in the transplanted mice.
Conclusion. This study demonstrated that improvement of mouse survival was achieved and recovery of olfactory function was promoted by transnasal transplantation of neural stem cells in the anosmic mouse model. These results indicate that stem cells might be one of the future modalities for treating olfactory impairment.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ahn JM / 2008 / Maintenance of regional difference in cellular composition of neurospheres derived from adult mouse olfactory bulb / Eur Arch Otorhinolaryngol 265 (4) : 429 ~
Andres RH / 2008 / Potential of adult neural stem cells in stroke therapy / Regen Med. 3 (6) : 893 ~ 905
Beites CL / 2005 / Identification and molecular regulation of neural stem cells in the olfactory epithelium / Exp Cell Res 306 (2) : 309 ~ 316
Buck L / 1991 / A novel multigene family may encode odorant receptors: a molecular basis for odor recognition / Cell 65 (1) : 175 ~ 187
Dimmeler S / 2009 / Cell therapy of acute myocardial infarction: open questions / Cardiology 113 (3) : 155 ~ 160
Andres RH / 2008 / Potential of adult neural stem cells in stroke therapy / Regen Med. 3 (6) : 893 ~ 905
Beites CL / 2005 / Identification and molecular regulation of neural stem cells in the olfactory epithelium / Exp Cell Res 306 (2) : 309 ~ 316
Buck L / 1991 / A novel multigene family may encode odorant receptors: a molecular basis for odor recognition / Cell 65 (1) : 175 ~ 187
Dimmeler S / 2009 / Cell therapy of acute myocardial infarction: open questions / Cardiology 113 (3) : 155 ~ 160
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