지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.6
- 수록면
- 163 - 167 (5page)
이용수
초록· 키워드
오류제보하기
Recent studies have shown that bone marrow derived-mesenchymal stem cells (BM-MSCs) improve neurological deficits when transplanted into animal models of neurological disorders. Cell replacement after neuronal degeneration in the adult central nervous system (CNS) depends on availability of specific cues to direct differentiation, specification and integration of newly born neurons into mature circuits. Following recent reports indicating that neurogenic signals may be reactivated in the adult injured CNS, here we asked whether embryonic cerebellar cells transplanted to the cerebella of adult neurodegenerative Niemann-Pick disease type C (NP-C) model mice. Most notably, there was a higher amount of Purkinje neurons and reduced significantly both of astrocytic and microglial activations in the cerebellum of embryonic cerebellar cells transplanted NP-C mice. These findings suggest that embryonic cerebellar cells transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Bae, J.S / 2005a / Neuroglial activation in Niemann-Pick Type C mice is suppressed by intracerebral transplantation of bone marrowderived mesenchymal stem cells 381 : 234 ~ 236
2. [학술지(정기간행물)] - Bae, J.S / 2005b / Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice 16 : 1006 ~ 1011
3. [학술지(정기간행물)] - Bae, J.S / 2007 / Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration 25 : 1307 ~ 1316
4. [학술지(정기간행물)] - Barone, F.C / 1999 / Inflammatory mediators and stroke: new opportunities for novel therapeutics 19 : 819 ~ 834
5. [학술지(정기간행물)] - Baudry, M / 2003 / Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: immunohistochemical observations of microglia and astroglia 184 : 887 ~ 903
2. [학술지(정기간행물)] - Bae, J.S / 2005b / Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice 16 : 1006 ~ 1011
3. [학술지(정기간행물)] - Bae, J.S / 2007 / Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration 25 : 1307 ~ 1316
4. [학술지(정기간행물)] - Barone, F.C / 1999 / Inflammatory mediators and stroke: new opportunities for novel therapeutics 19 : 819 ~ 834
5. [학술지(정기간행물)] - Baudry, M / 2003 / Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: immunohistochemical observations of microglia and astroglia 184 : 887 ~ 903
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UCI(KEPA) : I410-ECN-0101-2009-510-016363380