지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 181 - 188 (8page)
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Background: A stem cell is an undifferentiated cell that has the potential for self-renewal and differentiation. Adiposederived stem cells (ADSCs) have advantages in accessibility and abundance compared to other kinds of stem cells and produce many growth factors and hormones. Objective: We investigated whether ADSC cultured media could be used as a therapy for atopic dermatitis. Methods: ADSC cultured media was topically applied twice daily for 5 days to oxazolone-treated atopic dermatitis-like hairless mice.
Results: Topical application of ADSC cultured media improved the epidermal permeability barrier and keratinocyte differentiation, and restored the predominant Th2 phenotype when compared to vehicle. ADSC cultured mediatreated epidermis also showed an increase in the expression of antimicrobial peptides cathelin-related antimicrobial peptide, mouse beta-defensein 3. Conclusion: Topical ADSC cultured media could be useful in the treatment of atopic dermatitis.
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참고문헌 (16)
참고문헌 신청
Asahara T / 1997 / Isolation of putative progenitor endothelial cells for angiogenesis / Science 275 : 964 ~ 967
Crop MJ / 2010 / Human adipose tissue-derived mesenchymal stem cells induce explosive T-cell proliferation / Stem Cells Dev 19 : 1843 ~ 1853
Hong SP / 2010 / Topical calcitriol restores the impairment of epidermal permeability and antimicrobial barriers induced by corticosteroids / Br J Dermatol 162 : 1251 ~ 1260
Kern S / 2006 / Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue / Stem Cells 24 : 1294 ~ 1301
Krasnodembskaya A / 2010 / Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37 / Stem Cells 28 : 2229
Crop MJ / 2010 / Human adipose tissue-derived mesenchymal stem cells induce explosive T-cell proliferation / Stem Cells Dev 19 : 1843 ~ 1853
Hong SP / 2010 / Topical calcitriol restores the impairment of epidermal permeability and antimicrobial barriers induced by corticosteroids / Br J Dermatol 162 : 1251 ~ 1260
Kern S / 2006 / Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue / Stem Cells 24 : 1294 ~ 1301
Krasnodembskaya A / 2010 / Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37 / Stem Cells 28 : 2229
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