지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 93 - 100 (8page)
이용수
초록· 키워드
오류제보하기
Targeting protein kinases has been active area in drug discovery. The c-Jun N-terminal kinases (JNKs) have also been target for development of novel therapy in various diseases, since the roles of JNK signaling in pathological conditions were revealed in studies using jnk-deficient mice. Small molecule inhibitors and peptide inhibitors are identified for therapeutic intervention of JNK signaling pathway. SP-600125, an anthrapyrazole small molecule inhibitor for JNK with high potency and selectivity has been widely used for dissecting JNK signaling pathway. CC-401 is the first JNK inhibitor that went into clinical trial for inflammation and leukemia. Inhibitor for mixed lineage kinase (MLK), CEP-1347 also negatively regulates JNK signaling, and tried for potential use in Parkinson's disease. Cell-permeable peptide inhibitor D-JNKI-1 is being developed for the treatment of hearing loss. The current status of these JNK inhibitors and safety issue is discussed in the minireview.
목차
INTRODUCTION
INHIBITORS OF JNK SIGNALING CASCADE
SAFETY OF JNK SIGNALING INHIBITORS
CONCLUDING REMARKS
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The two-tiered activation of JNK1 prolongs cell survival prior to induced apoptosis
대한약학회 학술대회
2003 .01
-
UIP 환자에서 c-Jun N-terminal Kinase (JNK) 활성화에 관한 연구
Tuberculosis and Respiratory Diseases
2001 .01
-
Acebutolol, a Cardioselective Beta Blocker, Promotes Glucose Uptake in Diabetic Model Cells by Inhibiting JNK-JIP1 Interaction
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Klf4 activity is negatively controled in reprogramming Pluripotent stem cells by JNK1 and 2 signaling pathway
한국실험동물학회 학술발표대회 논문집
2014 .08
-
방사선에 의한 폐 섬유화증에서 c-Jun N-terminal Kinase(JNK)의 역할
Tuberculosis and Respiratory Diseases
2001 .01
-
Antitumor and apoptotic effect of quercetin in human melanoma cells involving JNK/P38 MAPK signaling activation
한국실험동물학회 학술발표대회 논문집
2019 .01
-
초대 배양한 닭 간세포 증식에 대한 estradiol-17β의 효과
한국가축위생학회지
2008 .01
-
The Development of Cell Signaling Inhibitors for Human Cancer Treatment
대한동의병리학회 학술대회논문집
2003 .07
-
Roles of p38 and JNK mitogen-activated protein kinase pathways during cantharidin-induced apoptosis in U937 cells
대한동의병리학회 학술대회논문집
2004 .08
-
N-(p-Coumaryol)-Tryptamine Suppresses the Activation of JNK/c-Jun Signaling Pathway in LPS-Challenged RAW264.7 Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
4주간 달리기 운동이 흰쥐의 전경골근에서 ERK 및 JNK의 활성화에 미치는 영향
동의생리병리학회지
2007 .02
-
Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation
Yonsei Medical Journal
2019 .01
-
Formaldehyde Induces Apoptosis in Cultured Embryonic Lung Cells
Laboratory Animal Research
2009 .03
-
파골세포 형성에 있어서 MLKs-JNK 경로의 역할 규명
대한골대사학회지
2012 .01
-
Glaucocalyxin A Activates FasL and Induces Apoptosis Through Activation of the JNK Pathway in Human Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
JNK/SAPK Is Required in Nitric Oxide-Induced Apoptosis in Osteoblasts
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
Requirement for JNK activation in costunolide-induced apoptosis
대한약학회 학술대회
2001 .01
-
The Effect of Epidermal Growth Factor on Cell Proliferation and Its Related Signal Pathways in Pig Hepatocytes
대한의생명과학회지
2006 .09
-
β-arrestin Promotes c-Jun N-terminal Kinase Mediated Apoptosis via a GABAR·β-arrestin·JNK Signaling Module
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Differential regulation of phospho-p38 and phospho-ERK by TCDD
한국수의병리학회 학술발표논문집
2003 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-014733876